2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)-4'-(butylamino)biphenyl-4-carboxylic acid

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Chemical Name:2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)-4'-(butylamino)biphenyl-4-carboxylic acid
CAS No.:917114-06-8
Molecular Formula:C₃₀H₃₃N₃O₆
Molecular Weight:531.609
Hs Code.:

Synonyms:2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)-4'-(butylamino)biphenyl-4-carboxylic acid

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Chemical Property of 2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)-4'-(butylamino)biphenyl-4-carboxylic acid

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Technology Process of 2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)-4'-(butylamino)biphenyl-4-carboxylic acid

There total 13 articles about 2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)-4'-(butylamino)biphenyl-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 917113-91-8
2-tert-butyl 4-methyl 2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-4'-[(trifluoroacetyl)amino]biphenyl-2,4-dicarboxylate

: 542-69-8
1-iodo-butane

: 917114-06-8
2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)-4'-(butylamino)biphenyl-4-carboxylic acid

Guidance literature:: 2-tert-butyl 4-methyl 2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-4'-[(trifluoroacetyl)amino]biphenyl-2,4-dicarboxylate; 1-iodo-butane; With potassium carbonate; In butanone; at 60 ℃; for 48h;

With sodium hydroxide; In methanol; water; for 2h; Heating;
DOI:10.1016/j.bmc.2006.09.071

Reference yield:

: 576170-38-2
3-(tert-butyl) 1-methyl 4-hydroxyisophthalate

: 917114-06-8
2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)-4'-(butylamino)biphenyl-4-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: 13.3 g / pyridine / CH₂Cl₂ / 0.5 h / 20 °C

2.1: bis(pinacolato)diboron; PPh₃; AcOK / PdCl₂(PPh₃)2 / toluene / Heating

2.2: 74 percent / Na₂CO₃ / Pd(PPh₃)2 / toluene / Heating

3.1: 72 percent / Fe; AcOH / 1 h / 60 °C

4.1: 70 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

5.1: 477 mg / H₂ / Pd/C / methanol / 12 h / 20 °C

6.1: 72 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 12 h / 20 °C

7.1: K₂CO₃ / butan-2-one / 48 h / 60 °C

7.2: 67 percent / NaOH / H₂O; methanol / 2 h / Heating

With pyridine; hydrogen; potassium acetate; iron; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; butanone; 2.2: Suzuki coupling;
DOI:10.1016/j.bmc.2006.09.071

Reference yield:

: 790230-23-8
3-tert-butyl 1-methyl 4-{[(trifluoromethyl)sulfonyl]oxy}isophthalate

: 917114-06-8
2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)-4'-(butylamino)biphenyl-4-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: bis(pinacolato)diboron; PPh₃; AcOK / PdCl₂(PPh₃)2 / toluene / Heating

1.2: 74 percent / Na₂CO₃ / Pd(PPh₃)2 / toluene / Heating

2.1: 72 percent / Fe; AcOH / 1 h / 60 °C

3.1: 70 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

4.1: 477 mg / H₂ / Pd/C / methanol / 12 h / 20 °C

5.1: 72 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 12 h / 20 °C

6.1: K₂CO₃ / butan-2-one / 48 h / 60 °C

6.2: 67 percent / NaOH / H₂O; methanol / 2 h / Heating

With pyridine; hydrogen; potassium acetate; iron; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; butanone; 1.2: Suzuki coupling;
DOI:10.1016/j.bmc.2006.09.071