2-tert-butyl 4-methyl 2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-4'-[(trifluoroacetyl)amino]biphenyl-2,4-dicarboxylate

Base Information

Chemical Name:2-tert-butyl 4-methyl 2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-4'-[(trifluoroacetyl)amino]biphenyl-2,4-dicarboxylate
CAS No.:917113-91-8
Molecular Formula:C₂₉H₂₆F₃N₃O₇
Molecular Weight:585.537
Hs Code.:

Synonyms:2-tert-butyl 4-methyl 2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-4'-[(trifluoroacetyl)amino]biphenyl-2,4-dicarboxylate

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Chemical Property of 2-tert-butyl 4-methyl 2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-4'-[(trifluoroacetyl)amino]biphenyl-2,4-dicarboxylate

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Technology Process of 2-tert-butyl 4-methyl 2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-4'-[(trifluoroacetyl)amino]biphenyl-2,4-dicarboxylate

There total 11 articles about 2-tert-butyl 4-methyl 2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-4'-[(trifluoroacetyl)amino]biphenyl-2,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 927879-78-5
4'-(2,2,2-trifluoro-acetylamino)-biphenyl-2,4,2'-tricarboxylic acid 2-tert-butyl ester 4-methyl ester

: 3544-24-9
3-Aminobenzamide

: 917113-91-8
2-tert-butyl 4-methyl 2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-4'-[(trifluoroacetyl)amino]biphenyl-2,4-dicarboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1016/j.bmc.2006.09.071

Reference yield:

: 576170-38-2
3-(tert-butyl) 1-methyl 4-hydroxyisophthalate

: 917113-91-8
2-tert-butyl 4-methyl 2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-4'-[(trifluoroacetyl)amino]biphenyl-2,4-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 13.3 g / pyridine / CH₂Cl₂ / 0.5 h / 20 °C

2.1: bis(pinacolato)diboron; PPh₃; AcOK / PdCl₂(PPh₃)2 / toluene / Heating

2.2: 74 percent / Na₂CO₃ / Pd(PPh₃)2 / toluene / Heating

3.1: 72 percent / Fe; AcOH / 1 h / 60 °C

4.1: 70 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

5.1: 477 mg / H₂ / Pd/C / methanol / 12 h / 20 °C

6.1: 72 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 12 h / 20 °C

With pyridine; hydrogen; potassium acetate; iron; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 2.2: Suzuki coupling;
DOI:10.1016/j.bmc.2006.09.071

Reference yield:

: 790230-23-8
3-tert-butyl 1-methyl 4-{[(trifluoromethyl)sulfonyl]oxy}isophthalate

: 917113-91-8
2-tert-butyl 4-methyl 2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-4'-[(trifluoroacetyl)amino]biphenyl-2,4-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: bis(pinacolato)diboron; PPh₃; AcOK / PdCl₂(PPh₃)2 / toluene / Heating

1.2: 74 percent / Na₂CO₃ / Pd(PPh₃)2 / toluene / Heating

2.1: 72 percent / Fe; AcOH / 1 h / 60 °C

3.1: 70 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

4.1: 477 mg / H₂ / Pd/C / methanol / 12 h / 20 °C

5.1: 72 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 12 h / 20 °C

With pyridine; hydrogen; potassium acetate; iron; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 1.2: Suzuki coupling;
DOI:10.1016/j.bmc.2006.09.071