(Z)-4(R)-<(tert-butyldiphenylsilyl)oxy>-6(S)-<2-<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>ethenyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran

Base Information

Chemical Name:(Z)-4(R)-<(tert-butyldiphenylsilyl)oxy>-6(S)-<2-<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>ethenyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran
CAS No.:122253-84-3
Molecular Formula:C₃₆H₄₀FNO₃Si
Molecular Weight:581.802
Hs Code.:

Synonyms:(Z)-4(R)-<(tert-butyldiphenylsilyl)oxy>-6(S)-<2-<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>ethenyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran

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Chemical Property of (Z)-4(R)-<(tert-butyldiphenylsilyl)oxy>-6(S)-<2-<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>ethenyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran

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Technology Process of (Z)-4(R)-<(tert-butyldiphenylsilyl)oxy>-6(S)-<2-<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>ethenyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran

There total 14 articles about (Z)-4(R)-<(tert-butyldiphenylsilyl)oxy>-6(S)-<2-<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>ethenyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 123930-14-3
(E)-4(R)-<(tert-butyldiphenylsilyl)oxy>-6(S)-<2-<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>ethenyl>-2(R)-methoxy-3,4,5,6-tetrahydro-2H-pyran

: 122253-84-3
(E)-4(R)-<(tert-butyldiphenylsilyl)oxy>-6(S)-<2-<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>ethenyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran

Guidance literature:: With acetic acid; In tetrahydrofuran; for 48h; Heating;
DOI:10.1021/jm00163a010

Reference yield: 60.0%

: 123930-32-5
(Z)-4(R)-<(tert-butyldiphenylsilyl)oxy>-6(S)-<2-<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>ethenyl>-2(R)-methoxy-3,4,5,6-tetrahydro-2H-pyran

: 122253-84-3
(Z)-4(R)-<(tert-butyldiphenylsilyl)oxy>-6(S)-<2-<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>ethenyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran

Guidance literature:: With acetic acid; In tetrahydrofuran; for 48h; Heating;
DOI:10.1021/jm00163a010

Reference yield:

: 65300-29-0,1611-38-7
4-(4-fluorophenyl)but-3-en-2-one

: 122253-84-3
(Z)-4(R)-<(tert-butyldiphenylsilyl)oxy>-6(S)-<2-<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>ethenyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 7 steps

1: 72 percent / KOH, EtOH / diethyl ether / 3 h

2: 91 percent / ammonium acetate, FCl₃*6H₂O / acetic acid / 4 h / Heating

3: 93 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Ambient temperature

4: 79 percent / PBr₃ / toluene; CH₂Cl₂ / 1 h / Ambient temperature

5: 89 percent / toluene / 5 h / Heating

6: 1.) 1.6 M n-BuLi / 1.) THF, hexane, 0.5 h, 2.) 1 h

7: 60 percent / aq. HOAc / tetrahydrofuran / 48 h / Heating

With ammonium acetate; potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; ethanol; phosphorus tribromide; acetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; acetic acid; toluene;
DOI:10.1021/jm00163a010