123930-14-3

Upstream product

• 86030-96-8 (2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-carbaldehyde 
• 122253-42-3 <2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>methyltriphenylphosphonium bromide 
• 65300-29-0 4-(4-fluorophenyl)but-3-en-2-one 
• 122253-19-4 bromo<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>methane 
• 122252-96-4 2,6-Dimethyl-4-(4-fluorophenyl)-3-hydroxymethyl-pyridine 
• 122252-67-9 methyl 2,6-dimethyl-4-(4-fluorophenyl)-pyridine-3-carboxylate 
• 122252-52-2 3-(4-fluorophenyl)-2-(1-oxoethyl)-5-oxohexanoic acid methyl ester 

Downstream Products

• 122253-84-3 (E)-4(R)-<(tert-butyldiphenylsilyl)oxy>-6(S)-<2-<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>ethenyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran 
• 122254-03-9 (E)-4(R)-<(tert-butyldiphenylsilyl)oxy>-6(S)-<2-<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>ethenyl>-3,4,5,6-tetrahydro-2H-pyran-2-one 

Relevant academic research and scientific papers

Synthesis and Biological Activity of New HMG-CoA Reductase Inhibitors. 1. Lactones of Pyridine- and Pyrimidine-Substituted 3,5-Dihydroxy-6-heptenoic (-heptanoic) Acids

Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids 2-4 have been synthesized.Extensive exploration of structure-activity relationships led to several compounds exceeding the inhibitory activity of mevinolin (1b)