tert-butyl ((3S,4S)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-4-methylpiperidin-3-yl)carbamate

Base Information

Chemical Name:tert-butyl ((3S,4S)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-4-methylpiperidin-3-yl)carbamate
CAS No.:1405129-23-8
Molecular Formula:C₂₈H₃₁F₂N₇O₂
Molecular Weight:535.597
Hs Code.:

Synonyms:tert-butyl ((3S,4S)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-4-methylpiperidin-3-yl)carbamate

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Chemical Property of tert-butyl ((3S,4S)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-4-methylpiperidin-3-yl)carbamate

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Technology Process of tert-butyl ((3S,4S)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-4-methylpiperidin-3-yl)carbamate

There total 21 articles about tert-butyl ((3S,4S)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-4-methylpiperidin-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl (1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-4-methylpiperidin-3-yl)carbamate

: 1405129-24-9
tert-butyl ((3R,4R)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-4-methylpiperidin-3-yl)carbamate

: 1405129-26-1
tert-butyl ((3R,4S)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-4-methylpiperidin-3-yl)carbamate

: 1405129-25-0
tert-butyl ((3S,4R)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-4-methylpiperidin-3-yl)carbamate

: 1405129-23-8
tert-butyl ((3S,4S)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-4-methylpiperidin-3-yl)carbamate

Guidance literature:: With Chiralpak AS-H column; Chiralpak AD-H column; In carbon dioxide; isopropyl alcohol; Resolution of racemate;

Reference yield:

: 1405127-64-1
3-(azidomethyl)-6-(2,6-difluorophenyl)pyridazine

: C₁₇H₂₄N₄O₂S

: 1405129-23-8
tert-butyl ((3S,4S)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-4-methylpiperidin-3-yl)carbamate

Guidance literature:: With trimethylphosphane; In tetrahydrofuran; at 20 ℃; for 0.75h;
DOI:10.1016/j.bmcl.2016.09.067

Reference yield:

: 3430-27-1
3-amino-4-methylpyridine

: 1405129-24-9
tert-butyl ((3R,4R)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-4-methylpiperidin-3-yl)carbamate

: 1405129-26-1
tert-butyl ((3R,4S)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-4-methylpiperidin-3-yl)carbamate

: 1405129-25-0
tert-butyl ((3S,4R)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-4-methylpiperidin-3-yl)carbamate

: 1405129-23-8
tert-butyl ((3S,4S)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-4-methylpiperidin-3-yl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / 20 °C

1.2: 21 h / 20 °C / Cooling with ice

2.1: hydrogen; acetic acid / 5% rhodium-on-charcoal; platinum(IV) oxide / 42 h / 70 °C / 10343.2 Torr

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 5 h / 60 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 56 h / 20 °C / Inert atmosphere

5.1: tetrahydrofuran / 4 h / 60 °C

6.1: trimethylphosphane / tetrahydrofuran / 0.83 h / 20 °C

6.2: 0.25 h / 20 °C

7.1: Chiralpak AS-H column; Chiralpak AD-H column / isopropyl alcohol; carbon dioxide / Resolution of racemate

With hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; trimethylphosphane; platinum(IV) oxide; 5% rhodium-on-charcoal; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; carbon dioxide; isopropyl alcohol;