4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-ethoxybenzoic acid

Base Information

Chemical Name:4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-ethoxybenzoic acid
CAS No.:636582-66-6
Molecular Formula:C₁₄H₁₉NO₅
Molecular Weight:281.309
Hs Code.:
DSSTox Substance ID:DTXSID201184619

Synonyms:SCHEMBL6249473;DTXSID201184619;4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-ethoxybenzoic acid;636582-66-6

Suppliers and Price of 4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-ethoxybenzoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-ethoxybenzoic acid

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:281.12632271
Heavy Atom Count:20
Complexity:350

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC1=C(C=CC(=C1)NC(=O)OC(C)(C)C)C(=O)O

Technology Process of 4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-ethoxybenzoic acid

There total 5 articles about 4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-ethoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 636582-64-4
ethyl 4-(tert-butoxy-carbonyl-amino)-2-ethoxy-benzoate

: 636582-66-6
4-(tert-butoxy-carbonyl-amino)-2-ethoxy-benzoic acid

Guidance literature:: ethyl 4-(tert-butoxy-carbonyl-amino)-2-ethoxy-benzoate; With sodium hydroxide; In ethanol; water; at 60 ℃; for 6h;

at 0 ℃;

Reference yield: 71.0%

: 617245-68-8
4-amino-2-ethoxybenzoic acid lithium salt

: 24424-99-5
di-tert-butyl dicarbonate

: 636582-66-6
4-(tert-butoxy-carbonyl-amino)-2-ethoxy-benzoic acid

Guidance literature:: 4-amino-2-ethoxybenzoic acid lithium salt; di-tert-butyl dicarbonate; In 1,4-dioxane; water; at 0 - 20 ℃; for 52.3333h;

With hydrogenchloride; In water;

Reference yield:

: 2486-66-0
2-ethoxy-4-nitrobenzoic acid

: 636582-66-6
4-(tert-butoxy-carbonyl-amino)-2-ethoxy-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 2 h / 70 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 0.5 h / 20 °C

3: triethylamine; dmap / 20 °C

4: sodium hydroxide; water; methanol / 20 °C

With methanol; dmap; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; triethylamine; sodium hydroxide; In methanol;