1-(2-chlorobenzyl)-2-(1-(4-isobutylphenyl)ethyl)-1H-benzo[d]imidazol-5-ol

Base Information

• Chemical Name: 1-(2-chlorobenzyl)-2-(1-(4-isobutylphenyl)ethyl)-1H-benzo[d]imidazol-5-ol
• CAS No.: 1382488-16-5
• Molecular Formula: C₂₆H₂₇ClN₂O
• Molecular Weight: 418.966
• Mol file: 1382488-16-5.mol

Synonyms:1-(2-chlorobenzyl)-2-(1-(4-isobutylphenyl)ethyl)-1H-benzo[d]imidazol-5-ol

Chemical Property of 1-(2-chlorobenzyl)-2-(1-(4-isobutylphenyl)ethyl)-1H-benzo[d]imidazol-5-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-chlorobenzyl)-2-(1-(4-isobutylphenyl)ethyl)-1H-benzo[d]imidazol-5-ol

There total 7 articles about 1-(2-chlorobenzyl)-2-(1-(4-isobutylphenyl)ethyl)-1H-benzo[d]imidazol-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.3%

1-(2-chlorobenzyl)-2-(1-(4-isobutylphenyl)ethyl)-5-methoxy-1H-benzo[d]imidazole (1382488-15-4) → 1-(2-chlorobenzyl)-2-(1-(4-isobutylphenyl)ethyl)-1H-benzo[d]imidazol-5-ol (1382488-16-5)

Guidance literature:

With hydrogen bromide; acetic acid; for 2h; Reflux;

DOI:10.1016/j.bmc.2012.04.048

Reference yield:

ibuprofen (15687-27-1,58560-75-1) → 1-(2-chlorobenzyl)-2-(1-(4-isobutylphenyl)ethyl)-1H-benzo[d]imidazol-5-ol (1382488-16-5)

Guidance literature:

Multi-step reaction with 4 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

3: acetic acid / 4 h / Reflux

4: hydrogen bromide; acetic acid / 2 h / Reflux

With oxalyl dichloride; hydrogen bromide; acetic acid; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/j.bmc.2012.04.048

Reference yield:

N1-(2-chlorobenzyl)-4-methoxybenzene-1,2-diamine (1382488-13-2) → 1-(2-chlorobenzyl)-2-(1-(4-isobutylphenyl)ethyl)-1H-benzo[d]imidazol-5-ol (1382488-16-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

2: acetic acid / 4 h / Reflux

3: hydrogen bromide; acetic acid / 2 h / Reflux

With hydrogen bromide; acetic acid; triethylamine; In dichloromethane;

DOI:10.1016/j.bmc.2012.04.048

upstream raw materials:

1-(2-chlorobenzyl)-2-(1-(4-isobutylphenyl)ethyl)-5-methoxy-1H-benzo[d]imidazole

N-(2-chlorobenzyl)-4-methoxy-2-nitroaniline

N¹-(2-chlorobenzyl)-4-methoxybenzene-1,2-diamine

N-(2-((2-chlorobenzyl)amino)-5-methoxyphenyl)-2-(4-isobutylphenyl)propanamide

Downstream raw materials:

1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)ethyl]-5-(pyridin-2-ylmethoxy)-1H-benzimidazole

2-[({1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)ethyl]-1H-benzimidazol-5-yl}oxy)methyl]quinoline