2-[({1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)ethyl]-1H-benzimidazol-5-yl}oxy)methyl]quinoline

Base Information

• Chemical Name: 2-[({1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)ethyl]-1H-benzimidazol-5-yl}oxy)methyl]quinoline
• CAS No.: 1382488-18-7
• Molecular Formula: C₃₆H₃₄ClN₃O
• Molecular Weight: 560.138
• Mol file: 1382488-18-7.mol

Synonyms:2-[({1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)ethyl]-1H-benzimidazol-5-yl}oxy)methyl]quinoline

Chemical Property of 2-[({1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)ethyl]-1H-benzimidazol-5-yl}oxy)methyl]quinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[({1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)ethyl]-1H-benzimidazol-5-yl}oxy)methyl]quinoline

There total 6 articles about 2-[({1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)ethyl]-1H-benzimidazol-5-yl}oxy)methyl]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2-Chloromethylquinoline (4377-41-7) + 1-(2-chlorobenzyl)-2-(1-(4-isobutylphenyl)ethyl)-1H-benzo[d]imidazol-5-ol (1382488-16-5) → 2-[({1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)ethyl]-1H-benzimidazol-5-yl}oxy)methyl]quinoline (1382488-18-7)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; caesium carbonate; In N,N-dimethyl-formamide; Inert atmosphere; Heating;

DOI:10.1016/j.bmc.2012.04.048

Reference yield:

N-(2-((2-chlorobenzyl)amino)-5-methoxyphenyl)-2-(4-isobutylphenyl)propanamide (1382488-14-3) → 2-[({1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)ethyl]-1H-benzimidazol-5-yl}oxy)methyl]quinoline (1382488-18-7)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 4 h / Reflux

2: hydrogen bromide; acetic acid / 2 h / Reflux

3: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / Inert atmosphere; Heating

With hydrogen bromide; tetra-(n-butyl)ammonium iodide; caesium carbonate; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.04.048

Reference yield:

1-chloro-2-(chloromethyl)benzene (611-19-8) → 2-[({1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)ethyl]-1H-benzimidazol-5-yl}oxy)methyl]quinoline (1382488-18-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

1.2: 10 h / Inert atmosphere; Reflux

2.1: tin(II) chloride dihdyrate / ethanol / 5 h / Reflux

3.1: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

4.1: acetic acid / 4 h / Reflux

5.1: hydrogen bromide; acetic acid / 2 h / Reflux

6.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / Inert atmosphere; Heating

With tin(II) chloride dihdyrate; hydrogen bromide; tetra-(n-butyl)ammonium iodide; caesium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.04.048

upstream raw materials:

2-Chloromethylquinoline

1-(2-chlorobenzyl)-2-(1-(4-isobutylphenyl)ethyl)-1H-benzo[d]imidazol-5-ol

N-(2-chlorobenzyl)-4-methoxy-2-nitroaniline

N-(2-((2-chlorobenzyl)amino)-5-methoxyphenyl)-2-(4-isobutylphenyl)propanamide