2-[({1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)ethyl]-1H-benzimidazol-5-yl}oxy)methyl]quinoline

Base Information

Chemical Name:2-[({1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)ethyl]-1H-benzimidazol-5-yl}oxy)methyl]quinoline
CAS No.:1382488-18-7
Molecular Formula:C₃₆H₃₄ClN₃O
Molecular Weight:560.138
Hs Code.:

Synonyms:2-[({1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)ethyl]-1H-benzimidazol-5-yl}oxy)methyl]quinoline

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Chemical Property of 2-[({1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)ethyl]-1H-benzimidazol-5-yl}oxy)methyl]quinoline

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Technology Process of 2-[({1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)ethyl]-1H-benzimidazol-5-yl}oxy)methyl]quinoline

There total 6 articles about 2-[({1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)ethyl]-1H-benzimidazol-5-yl}oxy)methyl]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 4377-41-7
2-Chloromethylquinoline

: 1382488-16-5
1-(2-chlorobenzyl)-2-(1-(4-isobutylphenyl)ethyl)-1H-benzo[d]imidazol-5-ol

: 1382488-18-7
2-[({1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)ethyl]-1H-benzimidazol-5-yl}oxy)methyl]quinoline

Guidance literature:: With tetra-(n-butyl)ammonium iodide; caesium carbonate; In N,N-dimethyl-formamide; Inert atmosphere; Heating;
DOI:10.1016/j.bmc.2012.04.048

Reference yield:

: 1382488-14-3
N-(2-((2-chlorobenzyl)amino)-5-methoxyphenyl)-2-(4-isobutylphenyl)propanamide

: 1382488-18-7
2-[({1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)ethyl]-1H-benzimidazol-5-yl}oxy)methyl]quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 4 h / Reflux

2: hydrogen bromide; acetic acid / 2 h / Reflux

3: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / Inert atmosphere; Heating

With hydrogen bromide; tetra-(n-butyl)ammonium iodide; caesium carbonate; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.04.048

Reference yield:

: 611-19-8
1-chloro-2-(chloromethyl)benzene

: 1382488-18-7
2-[({1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)ethyl]-1H-benzimidazol-5-yl}oxy)methyl]quinoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

1.2: 10 h / Inert atmosphere; Reflux

2.1: tin(II) chloride dihdyrate / ethanol / 5 h / Reflux

3.1: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

4.1: acetic acid / 4 h / Reflux

5.1: hydrogen bromide; acetic acid / 2 h / Reflux

6.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / Inert atmosphere; Heating

With tin(II) chloride dihdyrate; hydrogen bromide; tetra-(n-butyl)ammonium iodide; caesium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.04.048