(S)-6-((S)-4-benzyloxycarbonyl-4-(pyrrol-1-yl)-butyrylamino)-2-(carbazol-9-yl)-hexanoic acid methyl ester

Base Information

Chemical Name:(S)-6-((S)-4-benzyloxycarbonyl-4-(pyrrol-1-yl)-butyrylamino)-2-(carbazol-9-yl)-hexanoic acid methyl ester
CAS No.:1346772-37-9
Molecular Formula:C₃₅H₃₇N₃O₅
Molecular Weight:579.696
Hs Code.:

Synonyms:(S)-6-((S)-4-benzyloxycarbonyl-4-(pyrrol-1-yl)-butyrylamino)-2-(carbazol-9-yl)-hexanoic acid methyl ester

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Chemical Property of (S)-6-((S)-4-benzyloxycarbonyl-4-(pyrrol-1-yl)-butyrylamino)-2-(carbazol-9-yl)-hexanoic acid methyl ester

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Technology Process of (S)-6-((S)-4-benzyloxycarbonyl-4-(pyrrol-1-yl)-butyrylamino)-2-(carbazol-9-yl)-hexanoic acid methyl ester

There total 4 articles about (S)-6-((S)-4-benzyloxycarbonyl-4-(pyrrol-1-yl)-butyrylamino)-2-(carbazol-9-yl)-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 866139-30-2
(S)-2-pyrrol-1-yl-pentanedioic acid 1-benzyl ester

: 683753-88-0
(S)-methyl 6-amino-2-(carbazol-9-yl)hexanoate

: 1346772-37-9
(S)-6-((S)-4-benzyloxycarbonyl-4-(pyrrol-1-yl)-butyrylamino)-2-(carbazol-9-yl)-hexanoic acid methyl ester

Guidance literature:: (S)-2-pyrrol-1-yl-pentanedioic acid 1-benzyl ester; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; for 0.666667h; Inert atmosphere;

(S)-methyl 6-amino-2-(carbazol-9-yl)hexanoate; With triethylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.10.047

Reference yield:

: 883970-34-1
(S)-methyl 6-(benzyloxycarbonylamino)-2-(9H-carbazol-9-yl)hexanoate

: 1346772-37-9
(S)-6-((S)-4-benzyloxycarbonyl-4-(pyrrol-1-yl)-butyrylamino)-2-(carbazol-9-yl)-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium on activated charcoal; hydrogen / tetrahydrofuran; isopropyl alcohol / 1 h / 20 °C

2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0.67 h / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

With palladium on activated charcoal; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.tetlet.2011.10.047

Reference yield:

: 13030-09-6
1-benzyl L-glutamate

: 1346772-37-9
(S)-6-((S)-4-benzyloxycarbonyl-4-(pyrrol-1-yl)-butyrylamino)-2-(carbazol-9-yl)-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium acetate; acetic acid / water / 2 h / 75 °C

2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0.67 h / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

With sodium acetate; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; In dichloromethane; water; 1.1: Clauson-Kaas reaction;
DOI:10.1016/j.tetlet.2011.10.047