4-monomethoxytritylsulfenyl chloride

Base Information

• Chemical Name: 4-monomethoxytritylsulfenyl chloride
• CAS No.: 402734-78-5
• Molecular Formula: C₂₀H₁₇ClOS
• Molecular Weight: 340.873
• Mol file: 402734-78-5.mol

Synonyms:4-monomethoxytritylsulfenyl chloride

Chemical Property of 4-monomethoxytritylsulfenyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 4-monomethoxytritylsulfenyl chloride

There total 2 articles about 4-monomethoxytritylsulfenyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-monomethoxytriphenylmethanethiol (383401-03-4) → 4-monomethoxytritylsulfenyl chloride (402734-78-5)

Guidance literature:

With 1,3-dichloro-5,5-dimethylhydantoin; In 1,4-dioxane; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4039(01)01873-1

Reference yield:

p-methoxytrityl alcohol (847-83-6) → 4-monomethoxytritylsulfenyl chloride (402734-78-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / Lawesson's reagent / toluene / 75 °C

2: 65 percent / 1,3-dichloro-5,5-dimethylhydantoin / dioxane / 0.5 h / 20 °C

With Lawessons reagent; 1,3-dichloro-5,5-dimethylhydantoin; In 1,4-dioxane; toluene;

DOI:10.1016/S0040-4039(01)01873-1

Reference yield: 86.0%

cis-1,4-anhydroerythritol (4358-64-9) + 4-monomethoxytritylsulfenyl chloride (402734-78-5) → (+/-)-(3S,4R)-4-[[(4-methoxytrityl)sulfenyl]oxy]tetrahydrofuran-3-ol

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1.4h;

DOI:10.1081/NCN-200059288

upstream raw materials:

4-monomethoxytriphenylmethanethiol

p-methoxytrityl alcohol

Downstream raw materials:

5'-O-(4-monomethoxytrithylthio)-3'-O-tert-butyldimethylsilylthymidine

3'-O-tert-butyldimethylsilyl-5'-O-[[(3SR,4RS)-4-(4-methoxytrityl)sulfenyl]oxytetrahydrofuran-3-yl]oxycarbonylthymidine

3-N-(4-monomethoxytrithylthio)thymidine