5'-O-(4-monomethoxytrithylthio)-3'-O-tert-butyldimethylsilylthymidine

Base Information

Chemical Name:5'-O-(4-monomethoxytrithylthio)-3'-O-tert-butyldimethylsilylthymidine
CAS No.:402734-81-0
Molecular Formula:C₃₆H₄₄N₂O₆SSi
Molecular Weight:660.907
Hs Code.:

Synonyms:5'-O-(4-monomethoxytrithylthio)-3'-O-tert-butyldimethylsilylthymidine

Suppliers and Price of 5'-O-(4-monomethoxytrithylthio)-3'-O-tert-butyldimethylsilylthymidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-(4-monomethoxytrithylthio)-3'-O-tert-butyldimethylsilylthymidine

Chemical Property:

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Technology Process of 5'-O-(4-monomethoxytrithylthio)-3'-O-tert-butyldimethylsilylthymidine

There total 3 articles about 5'-O-(4-monomethoxytrithylthio)-3'-O-tert-butyldimethylsilylthymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 40733-27-5
3'-O-(t-butyldimethylsilyl)thymidine

: 402734-78-5
4-monomethoxytritylsulfenyl chloride

: 402734-81-0
5'-O-(4-monomethoxytrithylthio)-3'-O-tert-butyldimethylsilylthymidine

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1016/S0040-4039(01)01873-1

Reference yield:

: 847-83-6
p-methoxytrityl alcohol

: 402734-81-0
5'-O-(4-monomethoxytrithylthio)-3'-O-tert-butyldimethylsilylthymidine

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / Lawesson's reagent / toluene / 75 °C

2: 65 percent / 1,3-dichloro-5,5-dimethylhydantoin / dioxane / 0.5 h / 20 °C

3: 76 percent / lithium hexamethyldisilazide / tetrahydrofuran / 1 h / 20 °C

With Lawessons reagent; 1,3-dichloro-5,5-dimethylhydantoin; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; toluene;
DOI:10.1016/S0040-4039(01)01873-1

Reference yield:

: 383401-03-4
4-monomethoxytriphenylmethanethiol

: 402734-81-0
5'-O-(4-monomethoxytrithylthio)-3'-O-tert-butyldimethylsilylthymidine

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / 1,3-dichloro-5,5-dimethylhydantoin / dioxane / 0.5 h / 20 °C

2: 76 percent / lithium hexamethyldisilazide / tetrahydrofuran / 1 h / 20 °C

With 1,3-dichloro-5,5-dimethylhydantoin; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/S0040-4039(01)01873-1