(R)-4-(2-methylbutylphenyl) 4'-(2-methylbutyl)-4-biphenylcarboxylate

Base Information

• Chemical Name: (R)-4-(2-methylbutylphenyl) 4'-(2-methylbutyl)-4-biphenylcarboxylate
• CAS No.: 114884-44-5
• Molecular Formula: C₂₉H₃₄O₂
• Molecular Weight: 414.588
• Mol file: 114884-44-5.mol

Synonyms:(R)-4-(2-methylbutylphenyl) 4'-(2-methylbutyl)-4-biphenylcarboxylate

Chemical Property of (R)-4-(2-methylbutylphenyl) 4'-(2-methylbutyl)-4-biphenylcarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-(2-methylbutylphenyl) 4'-(2-methylbutyl)-4-biphenylcarboxylate

There total 12 articles about (R)-4-(2-methylbutylphenyl) 4'-(2-methylbutyl)-4-biphenylcarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(R)-4-(2-Methylbutyl)phenol (114828-69-2,69777-78-2) + (R)-4-Carboxy-4'-(2-methylbutyl)biphenyl (114828-67-0,67004-59-5) → (R)-4-(2-methylbutylphenyl) 4'-(2-methylbutyl)-4-biphenylcarboxylate (114884-44-5,69777-74-8)

Guidance literature:

With pyridine; dicyclohexyl-carbodiimide; toluene-4-sulfonic acid; at 25 ℃; for 48h;

DOI:10.1055/s-1988-27458

Reference yield:

(S)-(+)-1-bromo-2-methylbutane (99032-67-4) → (R)-4-(2-methylbutylphenyl) 4'-(2-methylbutyl)-4-biphenylcarboxylate (114884-44-5,69777-74-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) magnesium / 2.) PdCl₂(dppf) / 1.) ether; 2.) ether

2: aluminum, iodine / diethyl ether

3: pyridine, dicyclohexyl carbodimide, tosic acid

With pyridine; iodine; toluene-4-sulfonic acid; magnesium; dicyclohexyl-carbodiimide; aluminium; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In diethyl ether;

Reference yield:

4-bromo-1,1'-biphenyl (92-66-0) → (R)-4-(2-methylbutylphenyl) 4'-(2-methylbutyl)-4-biphenylcarboxylate (114884-44-5,69777-74-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) magnesium / 2.) PdCl₂(dppf) / 1.) ether; 2.) ether

2: bromine / CHCl₃

3: N,N-dimethylformamide

4: potassium hydroxyde / aq. ethanol

5: pyridine, dicyclohexyl carbodimide, tosic acid

With pyridine; potassium hydroxide; bromine; toluene-4-sulfonic acid; magnesium; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; chloroform;

upstream raw materials:

(R)-4-(2-Methylbutyl)phenol

(R)-4-Carboxy-4'-(2-methylbutyl)biphenyl

1-bromo-4-methoxy-benzene

4-bromo-1,1'-biphenyl