5-(2,4-difluoro-phenyl)-1-(2-hydroxy-ethyl)-pyrrolidin-2-one

Base Information

• Chemical Name: 5-(2,4-difluoro-phenyl)-1-(2-hydroxy-ethyl)-pyrrolidin-2-one
• CAS No.: 808186-38-1
• Molecular Formula: C₁₂H₁₃F₂NO₂
• Molecular Weight: 241.238
• Mol file: 808186-38-1.mol

Synonyms:5-(2,4-difluoro-phenyl)-1-(2-hydroxy-ethyl)-pyrrolidin-2-one

Chemical Property of 5-(2,4-difluoro-phenyl)-1-(2-hydroxy-ethyl)-pyrrolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2,4-difluoro-phenyl)-1-(2-hydroxy-ethyl)-pyrrolidin-2-one

There total 4 articles about 5-(2,4-difluoro-phenyl)-1-(2-hydroxy-ethyl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

7a-(2,4-difluoro-phenyl)-tetrahydro-pyrrolo[2,1-b]oxazol-5-one (808186-26-7) → 5-(2,4-difluoro-phenyl)-1-(2-hydroxy-ethyl)-pyrrolidin-2-one (808186-38-1)

Guidance literature:

With triethylsilane; titanium tetrachloride; In dichloromethane; at -78 - 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2004.09.001

Reference yield:

1,3-Difluorobenzene (372-18-9) → 5-(2,4-difluoro-phenyl)-1-(2-hydroxy-ethyl)-pyrrolidin-2-one (808186-38-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / aluminum chloride / 0 - 80 °C

2: 90 percent / aq. LiOH / tetrahydrofuran

3: 100 percent / toluene / 16 h / Heating

4: 80 percent / TiCl₄; Et₃SiH / CH₂Cl₂ / 16 h / -78 - 20 °C

With triethylsilane; lithium hydroxide; aluminium trichloride; titanium tetrachloride; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1016/j.bmcl.2004.09.001

Reference yield:

4-(2,4-difluorophenyl)-4-oxobutanoic acid (110931-77-6) → 5-(2,4-difluoro-phenyl)-1-(2-hydroxy-ethyl)-pyrrolidin-2-one (808186-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / toluene / 16 h / Heating

2: 80 percent / TiCl₄; Et₃SiH / CH₂Cl₂ / 16 h / -78 - 20 °C

With triethylsilane; titanium tetrachloride; In dichloromethane; toluene;

DOI:10.1016/j.bmcl.2004.09.001

upstream raw materials:

7a-(2,4-difluoro-phenyl)-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

1,3-Difluorobenzene

4-(2,4-difluorophenyl)-4-oxobutanoic acid

Downstream raw materials:

1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-difluoro-phenyl)-pyrrolidin-2-one