methyl 5-({[2-(ethyloxy)-2-oxoethyl]amino}carbonyl)-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-2.4-dihydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxylate

Base Information

• Chemical Name: methyl 5-({[2-(ethyloxy)-2-oxoethyl]amino}carbonyl)-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-2.4-dihydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxylate
• CAS No.: 1202704-74-2
• Molecular Formula: C₂₀H₁₈F₄N₂O₈
• Molecular Weight: 490.365

Synonyms:methyl 5-({[2-(ethyloxy)-2-oxoethyl]amino}carbonyl)-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-2.4-dihydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxylate

Chemical Property of methyl 5-({[2-(ethyloxy)-2-oxoethyl]amino}carbonyl)-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-2.4-dihydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxylate

Chemical Property:

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Technology Process of methyl 5-({[2-(ethyloxy)-2-oxoethyl]amino}carbonyl)-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-2.4-dihydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxylate

There total 1 articles about methyl 5-({[2-(ethyloxy)-2-oxoethyl]amino}carbonyl)-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-2.4-dihydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-2,4-dihydroxy-6oxo-1,6-dihydro-3-pyridinecarboxylate (1202704-72-0) + Glycine ethyl ester isocyanate (2949-22-6) → methyl 5-({[2-(ethyloxy)-2-oxoethyl]amino}carbonyl)-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-2.4-dihydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxylate (1202704-74-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In chloroform; at 110 ℃; for 3h;

Reference yield: 67.0%

2,4-Dimethoxybenzylamine (20781-20-8) + methyl 5-({[2-(ethyloxy)-2-oxoethyl]amino}carbonyl)-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-2.4-dihydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxylate (1202704-74-2) → N-[(5-[({[2,4-bis(methyloxy)phenyl]methyl}amino)carbonyl]-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-4,6-dihydroxy-2-oxo-1,2-dihydro-3-pyridinyl)carbonyl]glycine (1202699-25-9)

Guidance literature:

2,4-Dimethoxybenzylamine; methyl 5-({[2-(ethyloxy)-2-oxoethyl]amino}carbonyl)-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-2.4-dihydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxylate; In 1,4-dioxane; at 150 ℃; for 0.5h; Microwave irradiation; Sealed tube;

With sodium hydroxide; In 1,4-dioxane;

With hydrogenchloride; In 1,4-dioxane; water; ethyl acetate;

Reference yield: 62.0%

2-fluoro-4-(trifluoromethyl)benzylamine (239087-05-9) + methyl 5-({[2-(ethyloxy)-2-oxoethyl]amino}carbonyl)-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-2.4-dihydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxylate (1202704-74-2) → N-({1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-5-[({[2-fluoro-4-(trifluoromethyl)phenyl]methyl}amino)carbonyl]-4,6-dihydroxy-2-oxo-1,2-dihydro-3-pyridinyl}carbonyl)glycine (1202699-17-9)

Guidance literature:

2-fluoro-4-(trifluoromethyl)benzylamine; methyl 5-({[2-(ethyloxy)-2-oxoethyl]amino}carbonyl)-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-2.4-dihydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxylate; In 1,4-dioxane; at 150 ℃; for 0.5h; Microwave irradiation; Sealed tube;

With sodium hydroxide; In 1,4-dioxane;

With hydrogenchloride; In 1,4-dioxane; water; ethyl acetate;

upstream raw materials:

methyl 1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-2,4-dihydroxy-6oxo-1,6-dihydro-3-pyridinecarboxylate

Glycine ethyl ester isocyanate

Downstream raw materials:

N-[(5-({[(4-fluorophenyl)methyl]amino}carbonyl)-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-4,6-dihydroxy-2-oxo-1,2-dihydro-3-pyridinyl)carbonyl]glycine

N-[(5-[({[2,4-bis(methyloxy)phenyl]methyl}amino)carbonyl]-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-4,6-dihydroxy-2-oxo-1,2-dihydro-3-pyridinyl)carbonyl]glycine

N-({1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-5-[({[2-fluoro-4-(trifluoromethyl)phenyl]methyl}amino)carbonyl]-4,6-dihydroxy-2-oxo-1,2-dihydro-3-pyridinyl}carbonyl)glycine

N-({1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-4,6-dihydroxy-5-[({[4-hydroxy-3-(methyloxy)phenyl]methyl}amino)carbonyl]-2-oxo-1,2-dihydro-3-pyridinyl}carbonyl)glycine

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