tert-butyl((1-(3-methoxy-2-(methoxymethoxy)phenyl)prop-2-yn-1-yl)oxy)dimethylsilane

Base Information

Chemical Name:tert-butyl((1-(3-methoxy-2-(methoxymethoxy)phenyl)prop-2-yn-1-yl)oxy)dimethylsilane
CAS No.:1578204-54-2
Molecular Formula:C₁₈H₂₈O₄Si
Molecular Weight:336.503
Hs Code.:

Synonyms:tert-butyl((1-(3-methoxy-2-(methoxymethoxy)phenyl)prop-2-yn-1-yl)oxy)dimethylsilane

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Chemical Property of tert-butyl((1-(3-methoxy-2-(methoxymethoxy)phenyl)prop-2-yn-1-yl)oxy)dimethylsilane

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Technology Process of tert-butyl((1-(3-methoxy-2-(methoxymethoxy)phenyl)prop-2-yn-1-yl)oxy)dimethylsilane

There total 1 articles about tert-butyl((1-(3-methoxy-2-(methoxymethoxy)phenyl)prop-2-yn-1-yl)oxy)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 5779-96-4
3-methoxy-2-(methoxymethyloxy)benzaldehyde

: 1066-26-8
sodium acetylide

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1578204-54-2
tert-butyl((1-(3-methoxy-2-(methoxymethoxy)phenyl)prop-2-yn-1-yl)oxy)dimethylsilane

Guidance literature:: 3-methoxy-2-(methoxymethyloxy)benzaldehyde; sodium acetylide; In tetrahydrofuran; toluene; for 12h;

tert-butyldimethylsilyl chloride; In tetrahydrofuran; toluene;
DOI:10.1021/ol5002945

Reference yield: 86.0%

: 1578204-54-2
tert-butyl((1-(3-methoxy-2-(methoxymethoxy)phenyl)prop-2-yn-1-yl)oxy)dimethylsilane

: 87184-81-4
4-(tert-butyldimethylsilanyloxy)butanal

: 1578204-58-6
1-(3-methoxy-2-(methoxymethoxy)phenyl)-1,7-bis(tert-butyldimethylsiloxy)hept-2-yn-4-ol

Guidance literature:: tert-butyl((1-(3-methoxy-2-(methoxymethoxy)phenyl)prop-2-yn-1-yl)oxy)dimethylsilane; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 5h;

4-(tert-butyldimethylsilanyloxy)butanal; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h;
DOI:10.1021/ol5002945

Reference yield:

: 1578204-54-2
tert-butyl((1-(3-methoxy-2-(methoxymethoxy)phenyl)prop-2-yn-1-yl)oxy)dimethylsilane

: 1578204-61-1
4-(benzyloxy)-1-(3-methoxy-2-(methoxymethoxy)phenyl)-1,7-bis(tert-butyldimethylsiloxy)hept-2-yne

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 5 h / -78 - 20 °C

1.2: 2 h / -78 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 5 h / 20 °C

With n-butyllithium; sodium hydride; diisopropylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/ol5002945