N-[4-[(Trifluoroacetyl)aMino]benzoyl]-L-glutaMic Acid DiMethyl Ester

Base Information

Chemical Name:N-[4-[(Trifluoroacetyl)aMino]benzoyl]-L-glutaMic Acid DiMethyl Ester
CAS No.:233600-78-7
Molecular Formula:C₁₆H₁₇F₃N₂O₆
Molecular Weight:390.316
Hs Code.:
Mol file:233600-78-7.mol

Synonyms:dimethyl p-trifluoroacetamidobenzoyl-L-glutamate

Suppliers and Price of N-[4-[(Trifluoroacetyl)aMino]benzoyl]-L-glutaMic Acid DiMethyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-[4-[(Trifluoroacetyl)amino]benzoyl]-L-glutamicAcidDimethylEster
250mg
$ 1100.00

Medical Isotopes, Inc.
N-[4-[(Trifluoroacetyl)amino]benzoyl]-L-glutamicAcidDimethylEster
25 mg
$ 625.00

Total 1 raw suppliers

Chemical Property of N-[4-[(Trifluoroacetyl)aMino]benzoyl]-L-glutaMic Acid DiMethyl Ester

Chemical Property:

Boiling Point:536.3±50.0 °C(Predicted)
PKA:9.52±0.70(Predicted)
Density:1.366±0.06 g/cm3(Predicted)
Solubility.:Methanol

Purity/Quality:: N-[4-[(Trifluoroacetyl)amino]benzoyl]-L-glutamicAcidDimethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses N-[4-[(Trifluoroacetyl)amino]benzoyl]-L-glutamic Acid Dimethyl Ester is an intermediate in the synthesis of Folic Acid (F680300), an vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA by acting as a cofactor in biological reactions involving folate.

Technology Process of N-[4-[(Trifluoroacetyl)aMino]benzoyl]-L-glutaMic Acid DiMethyl Ester

There total 4 articles about N-[4-[(Trifluoroacetyl)aMino]benzoyl]-L-glutaMic Acid DiMethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 404-26-2
4-(trifluoroacetamido)benzoic acid

: 23150-65-4
L-glutamic dimethyl ester hydrochloride

: 233600-78-7
dimethyl p-trifluoroacetamidobenzoyl-L-glutamate

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; at -5 ℃; for 48h;

Reference yield:

: 56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
L-glutamic acid

: 233600-78-7
dimethyl p-trifluoroacetamidobenzoyl-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / SOCl₂ / 18 h / Ambient temperature

2: 70 percent / HOBt, DCC, DIEA / tetrahydrofuran / 48 h / -5 °C

With thionyl chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran;

Reference yield:

: 126063-08-9
2,2,2-trifluoro-N-(4-iodophenyl)acetamide

: 233600-78-7
dimethyl p-trifluoroacetamidobenzoyl-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) ether, hexane, -78 deg C, 2 h, 2.) ether, hexane, -78 deg C to r.t.

2: 70 percent / HOBt, DCC, DIEA / tetrahydrofuran / 48 h / -5 °C

With n-butyllithium; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran;