4-(4-methylpiperazin-1-yl)-5-(1H-1,2,4-triazol-3-yl)-1-phenylpyridin-2(1H)-onehydrogen fumarate

Base Information

Chemical Name:4-(4-methylpiperazin-1-yl)-5-(1H-1,2,4-triazol-3-yl)-1-phenylpyridin-2(1H)-onehydrogen fumarate
CAS No.:1398117-26-4
Molecular Formula:C₄H₄O₄*C₁₈H₂₀N₆O
Molecular Weight:452.47
Hs Code.:

Synonyms:4-(4-methylpiperazin-1-yl)-5-(1H-1,2,4-triazol-3-yl)-1-phenylpyridin-2(1H)-onehydrogen fumarate

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Chemical Property of 4-(4-methylpiperazin-1-yl)-5-(1H-1,2,4-triazol-3-yl)-1-phenylpyridin-2(1H)-onehydrogen fumarate

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Technology Process of 4-(4-methylpiperazin-1-yl)-5-(1H-1,2,4-triazol-3-yl)-1-phenylpyridin-2(1H)-onehydrogen fumarate

There total 5 articles about 4-(4-methylpiperazin-1-yl)-5-(1H-1,2,4-triazol-3-yl)-1-phenylpyridin-2(1H)-onehydrogen fumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 109-01-3
1-methyl-piperazine

: 1398117-24-2
4-phenoxy-5-(1H-1,2,4-triazol-3-yl)-1-phenylpyridin-2(1H)-one

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 1398117-26-4
4-(4-methylpiperazin-1-yl)-5-(1H-1,2,4-triazol-3-yl)-1-phenylpyridin-2(1H)-onehydrogen fumarate

Guidance literature:: 1-methyl-piperazine; 4-phenoxy-5-(1H-1,2,4-triazol-3-yl)-1-phenylpyridin-2(1H)-one; at 150 ℃; for 1h; Microwave irradiation;

(2E)-but-2-enedioic acid; In diethyl ether;

Reference yield:

: 80421-15-4
1,6-Dihydro-4-hydroxy-6-oxo-1-phenyl-3-pyridincarbonsaeure-methylester

: 1398117-26-4
4-(4-methylpiperazin-1-yl)-5-(1H-1,2,4-triazol-3-yl)-1-phenylpyridin-2(1H)-onehydrogen fumarate

Guidance literature:: Multi-step reaction with 6 steps

1: trichlorophosphate / 3 h / Reflux

2: N,N-dimethyl-formamide / 4 h / 120 °C

3: ammonia / methanol / 15 h / 20 °C

4: 1.5 h / 120 °C

5: hydrazine hydrate; acetic acid / 1.5 h / 90 °C

6: 1 h / 150 °C / Microwave irradiation

With ammonia; hydrazine hydrate; acetic acid; trichlorophosphate; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1398117-80-0
methyl 4-chloro-6-oxo-1-phenyl-1,6-dihydro-pyridine-3-carboxylate

: 1398117-26-4
4-(4-methylpiperazin-1-yl)-5-(1H-1,2,4-triazol-3-yl)-1-phenylpyridin-2(1H)-onehydrogen fumarate

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 4 h / 120 °C

2: ammonia / methanol / 15 h / 20 °C

3: 1.5 h / 120 °C

4: hydrazine hydrate; acetic acid / 1.5 h / 90 °C

5: 1 h / 150 °C / Microwave irradiation

With ammonia; hydrazine hydrate; acetic acid; In methanol; N,N-dimethyl-formamide;