80421-15-4

Upstream product

• 80421-14-3 2-(Anilinomethylen)-3-oxopentandisaeure-dimethylester 
• 62-53-3 aniline 
• 610271-66-4 dimethyl 2-[(dimethylamino)methylidene]-3-oxopentane-1,5-dioate 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 80421-14-3 dimethyl 3-oxo-2-[(phenylamino)methylene]glutarate 
• 67-56-1 methanol 
• 1398117-79-7 4-hydroxy-6-oxo-1-phenyl-1,6-dihydropyri-dine-3-carboxylic acid 

Downstream Products

• 1398117-80-0 methyl 4-chloro-6-oxo-1-phenyl-1,6-dihydro-pyridine-3-carboxylate 
• 1398117-83-3 N,N-dimethyl-N'-[(6-oxo-4-phenoxy-1-phenyl-1,6-dihydropyridin-3-yl)carbonyl]formamidine 
• 1398117-24-2 4-phenoxy-5-(1H-1,2,4-triazol-3-yl)-1-phenylpyridin-2(1H)-one 
• 1398117-26-4 4-(4-methylpiperazin-1-yl)-5-(1H-1,2,4-triazol-3-yl)-1-phenylpyridin-2(1H)-onehydrogen fumarate 
• 1394014-88-0 C₁₉H₁₂N₂O₃ 
• 1394014-89-1 C₁₈H₁₂ClNO₃ 
• 1394014-90-4 C₁₇H₁₂N₂O₃ 
• 1394014-87-9 C₁₈H₁₃NO₃ 
• 1394014-94-8 C₂₁H₂₀N₂O₃ 
• 1394014-95-9 C₂₅H₂₀N₂O₂ 
• 1394014-96-0 C₂₃H₂₅N₃O₂ 
• 1394014-97-1 C₂₂H₂₂N₂O₂ 
• 1394014-98-2 C₂₁H₁₉ClN₂O₃ 
• 1394014-99-3 C₂₅H₁₉ClN₂O₂ 

Relevant academic research and scientific papers

NEW PYRIDAZINONE AND PYRIDONE COMPOUNDS

The invention relates to pyridazinone and pyridone com- pounds having formula (I) or (I'), and pharmaceutically acceptable salts, hydrates, and solvates thereof (I) wherein R1 / R4 and X and X3 are as defined in the claims

Diversity-oriented synthesis of 1-substituted 4-aryl-6-oxo-1,6- dihydropyridine-3-carboxamides.

A simple five-step diversity-oriented synthesis of 1-substituted 4-aryl-6-oxo-1,6-dihydropyridine-3-carboxamides was developed. Treatment of dimethyl 2-((dimethylamino)methylidene)-3-oxopentanedioate with twenty primary amines gave 1-substituted methyl 4-hydroxy-6-oxo-1,6-dihydropyridine-3- carboxylates. Transformation into the corresponding 4-tosyloxy and 4-chloro derivatives, followed by Suzuki-Miyaura arylations gave a series of eleven N-substituted methyl 4-aryl-6-oxo-1,6-dihydropyridine-3-carboxylates. Combinatorial screening was employed to establish suitable reaction conditions for Suzuki-Miyaura arylation of N-alkylpyridones. Hydrolysis of the esters followed by parallel solution-phase amidation of the corresponding carboxylic acids with primary and secondary amines furnished a library of seventeen final products.

β,β-Diacyl-enamine und -enole, 9. Zur Darstellung von Aminomethylenderivaten offenkettiger CH2-acider Verbindungen

The reaction of a combination of primary or secondary aromatic or aliphatic amines with orthocarboxylic esters upon a variety of open-chain CH2-acidic molecules gives N-substituted aminoalkylidene derivatives.The method is highly recommended for methylene