1-(2-(4-bromo-3-(trifluoromethyl)phenoxy)ethyl)cyclopropanol

Base Information

• Chemical Name: 1-(2-(4-bromo-3-(trifluoromethyl)phenoxy)ethyl)cyclopropanol
• CAS No.: 1544739-58-3
• Molecular Formula: C₁₂H₁₂BrF₃O₂
• Molecular Weight: 325.125
• Mol file: 1544739-58-3.mol

Synonyms:1-(2-(4-bromo-3-(trifluoromethyl)phenoxy)ethyl)cyclopropanol

Chemical Property of 1-(2-(4-bromo-3-(trifluoromethyl)phenoxy)ethyl)cyclopropanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-(2-(4-bromo-3-(trifluoromethyl)phenoxy)ethyl)cyclopropanol

There total 2 articles about 1-(2-(4-bromo-3-(trifluoromethyl)phenoxy)ethyl)cyclopropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-(4-bromo-3-(trifluoromethyl)phenoxy)propanoate (1544739-57-2) + ethylmagnesium bromide (925-90-6) → 1-(2-(4-bromo-3-(trifluoromethyl)phenoxy)ethyl)cyclopropanol (1544739-58-3)

Guidance literature:

methyl 3-(4-bromo-3-(trifluoromethyl)phenoxy)propanoate; With titanium(IV) isopropylate; In tetrahydrofuran; for 0.166667h;

ethylmagnesium bromide; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield:

3-trifluoromethyl-4-bromophenol (320-49-0) → 1-(2-(4-bromo-3-(trifluoromethyl)phenoxy)ethyl)cyclopropanol (1544739-58-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium methylate / Reflux; Inert atmosphere

2.1: titanium(IV) isopropylate / tetrahydrofuran / 0.17 h

2.2: 1 h / 0 - 20 °C

With titanium(IV) isopropylate; sodium methylate; In tetrahydrofuran;

Reference yield:

1-(2-(4-bromo-3-(trifluoromethyl)phenoxy)ethyl)cyclopropanol (1544739-58-3) + 4-[2-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyloxy]-1,1a,6,6a-tetrahydro-3-aza-cyclopropa[a]indene-1-carboxylic acid ethyl ester (1544739-24-3) → (5aR,6S,6aS)-ethyl 3-((4-fluoro-4’-(2-(1-hydroxycyclopropyl)ethoxy)-2’-(trifluoromethyl)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]-cyclopenta[1,2-c]pyridine-6-carboxylate (1544739-59-4)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; In tetrahydrofuran; water; at 100 ℃; for 0.5h; Microwave irradiation;

upstream raw materials:

methyl 3-(4-bromo-3-(trifluoromethyl)phenoxy)propanoate

ethylmagnesium bromide

3-trifluoromethyl-4-bromophenol

Downstream raw materials:

(5aR,6S,6aS)-ethyl 3-((4-fluoro-4’-(2-(1-hydroxycyclopropyl)ethoxy)-2’-(trifluoromethyl)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]-cyclopenta[1,2-c]pyridine-6-carboxylate

(5aR,6S,6aS)-3-((4-fluoro-4’-(2-(1-hydroxycyclopropyl)ethoxy)-2’-(trifluoromethyl)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid