320-49-0

Usage

Chemical Properties

light yellow crystalline powder

InChI:InChI=1/C7H3Cl2F3/c8-4-1-2-6(9)5(3-4)7(10,11)12/h1-3H

Upstream product

• 393-36-2 4-bromo-3-(trifluoromethyl)aniline 
• 98-17-9 3-Trifluoromethylphenol 
• 7664-93-9 sulfuric acid 

Downstream Products

• 684249-62-5 1-(3-{[4-bromo-3-(trifluoromethyl)phenyl]oxy}propyl)piperidine 
• 400-72-6 3-trifluoromethyl-4-bromo-1-methoxy-benzene 
• 927435-99-2 2'-fluoro-2-trifluoromethyl-biphenyl-4-ol 
• 156605-95-7 4-bromo-1-ethoxy-3-trifluoromethyl-benzene 
• 1186482-11-0 1-bromo-4-propoxy-2-(trifluoromethyl)benzene 
• 1203486-76-3 (S)-4-((4-bromo-3-(trifluoromethyl)phenoxy)methyl)-2,2-dimethyl-1,3-dioxolane 
• 1613720-62-9 6-(1-benzhydryl-3-methylazetidin-3-yloxy)-4-methyl-7-trifluoromethyl-2-(2-trimethylsilanylethoxymethyl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one 
• 1613720-11-8 6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one 
• 1613720-10-7 6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2-(2-trimethylsilanylethoxymethyl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one 
• 1613719-78-0 2-amino-4-bromo-5-(trifluoromethyl)phenol 
• 1613719-77-9 4-bromo-2-nitro-5-(trifluoromethyl)phenol 
• 1544739-56-1 (5aR,6S,6aS)-3-((4-fluoro-4’-(2-(1-hydroxycyclopropyl)ethoxy)-2’-(trifluoromethyl)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid 

Relevant academic research and scientific papers

Regioselective monobromination of phenols with KBr and ZnAl–BrO3?–layered double hydroxides

The regioselective mono-bromination of phenols has been successfully developed with KBr and ZnAl–BrO3?–layered double hydroxides (abbreviated as ZnAl–BrO3?–LDHs) as brominating reagents. The para site is much favorable and the ortho site takes the priority if para site is occupied. This reaction featured with excellent regioselectivity, cheap brominating reagents, mild reaction condition, high atom economy, broad substrate scope, and provided an efficient method to synthesize bromophenols.

NEW THIADIAZOLE DERIVATIVES

The present invention relates to thiadiazole derivatives of formula (I), to processes for their preparation and to pharmaceutical compositions containing them. These compounds are potent agonists of S1P1 receptors and thus, they are useful In the treatment, prevention or suppression of diseases and disorders known to be susceptible to improvement by sphingosine-1-phosphate receptors agonists (S1P1), such as autoimmune diseases, chronic immune and inflammatory diseases, transplant rejection, malignant neoplastic diseases, angiogenic-related disorders, pain, neurological diseases, viral and infectious diseases.

SUBSTITUTED PIPERAZINES, (1,4) DIASZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS

The present invention relates to novel piperazine and azepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurodegenerative disorders including Alzheimer's disease.

Pesticidal pyrimidine compounds

Compounds of formula (I) in which X1 and X2 each represents oxygen; S(O)n, n being 0, 1 or 2; or CO, CH2 or NR, R being hydrogen or alkyl; R1 and R10 are each hydrogen or halogen; R2 and R9 are each hydrogen, halogen, cyano, nitro, alkyl, halo-alkyl, alkoxy, alkylthio, amino, mono- or di-alkylamino, alkoxyalkyl, haloalkoxyalkyl or alkoxycarbonyl; R3 and R8 are each hydrogen, chlorine, alkyl, haloalkyl, haloalkenyl, halo-alkynyl, haloalkoxy, haloalkoxycarbenyl, haloalkylthio, haloalkoxyalkyl, haloalkylsulphinyl, or haloalkylsulphonyl, nitro or cyano; R4 and R7 are each hydrogen, halogen, alkyl or alkoxy; R5 is hydrogen, halogen, cyano, alkyl, haloalkyl, alkoxy, alkylthio, alkylsulphonyl or phenyl; and R6 is hydrogen or, when R5 is hydrogen, alkyl; provided that either each phenyl is unsubstituted or at least one of R3 and R8 is not hydrogen, have useful pesticidal activity.

2-trifluoromethyl-4-hydroxybenzoic acid

Disclosed is a novel compound 2-trifluoromethyl-4-hydroxybenzoic acid represented by the formula: STR1

Process for the preparation of 2-trifluoromethyl-4-hydroxybenzoic acid

Disclosed is a novel compound 2-trifluoromethyl--4-hydroxybenzoic acid represented by the formula: