320-49-0

Basic information

• Product Name: 4-Bromo-3-(trifluoromethyl)phenol
• Synonyms: 4-Bromo-3-(trifluoromethyl)phenol, 4-Bromo-alpha,alpha,alpha-trifluoro-m-cresol;Phenol,4-bromo-3-(trifluoromethyl)-;2-BROMO-5-HYDROXYBENZOTRIFLUORIDE;4-BROMO-3-(TRIFLUOROMETHYL)PHENOL;3-TRIFLUOROMETHYL-4-BROMO PHENOL;3-Trifluoromethyl-4-Bromo Phenol 4-Bromo-3-Trifluoromethylphenol;2-Bromo-5-hydroxybenzotrifluoride 99%;2-Bromo-5-hydroxybenzotrifluoride99%
• CAS NO: 320-49-0
• Molecular Formula: C₇H₄BrF₃O
• Molecular Weight: 241.01
• EINECS: 206-276-0
• Product Categories: Phenol&Thiophenol&Mercaptan;Miscellaneous
• Mol File: 320-49-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 44-46°C
• Boiling Point: 234.852 °C at 760 mmHg
• Flash Point: >110°(230°F)
• Appearance: Yellow/Solid
• Density: 1.752 g/cm³
• Vapor Pressure: 1.24mmHg at 25°C
• Refractive Index: 1.47
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 8.39±0.18(Predicted)
• CAS DataBase Reference: 4-Bromo-3-(trifluoromethyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-3-(trifluoromethyl)phenol(320-49-0)
• EPA Substance Registry System: 4-Bromo-3-(trifluoromethyl)phenol(320-49-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: 8
• Hazardous Substances Data: 320-49-0(Hazardous Substances Data)

Usage

Chemical Properties

light yellow crystalline powder

InChI:InChI=1/C7H3Cl2F3/c8-4-1-2-6(9)5(3-4)7(10,11)12/h1-3H

Upstream product

• 98-17-9 3-Trifluoromethylphenol 
• 7664-93-9 sulfuric acid 
• 393-36-2 4-bromo-3-(trifluoromethyl)aniline 

Downstream Products

• 927435-99-2 2'-fluoro-2-trifluoromethyl-biphenyl-4-ol 
• 1613719-77-9 4-bromo-2-nitro-5-(trifluoromethyl)phenol 
• 1613719-78-0 2-amino-4-bromo-5-(trifluoromethyl)phenol 
• 1609581-47-6 4-[4-bromo-3-(trifluoromethyl)phenoxy]furo[3,2-c]pyridine 

Relevant articles and documents

Regioselective monobromination of phenols with KBr and ZnAl–BrO3?–layered double hydroxides

The regioselective mono-bromination of phenols has been successfully developed with KBr and ZnAl–BrO3?–layered double hydroxides (abbreviated as ZnAl–BrO3?–LDHs) as brominating reagents. The para site is much favorable and the ortho site takes the priority if para site is occupied. This reaction featured with excellent regioselectivity, cheap brominating reagents, mild reaction condition, high atom economy, broad substrate scope, and provided an efficient method to synthesize bromophenols.

SUBSTITUTED PIPERAZINES, (1,4) DIASZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS

The present invention relates to novel piperazine and azepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurodegenerative disorders including Alzheimer's disease.

2-trifluoromethyl-4-hydroxybenzoic acid

Disclosed is a novel compound 2-trifluoromethyl-4-hydroxybenzoic acid represented by the formula: STR1