3-(6-chloro-pyridin-3-yl)-3-oxo-2-phenyl-propionic acid ethyl ester

Base Information

• Chemical Name: 3-(6-chloro-pyridin-3-yl)-3-oxo-2-phenyl-propionic acid ethyl ester
• CAS No.: 1026038-09-4
• Molecular Formula: C₁₆H₁₄ClNO₃
• Molecular Weight: 303.745
• Mol file: 1026038-09-4.mol

Synonyms:3-(6-chloro-pyridin-3-yl)-3-oxo-2-phenyl-propionic acid ethyl ester

Chemical Property of 3-(6-chloro-pyridin-3-yl)-3-oxo-2-phenyl-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-(6-chloro-pyridin-3-yl)-3-oxo-2-phenyl-propionic acid ethyl ester

There total 1 articles about 3-(6-chloro-pyridin-3-yl)-3-oxo-2-phenyl-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-Chloronicotinoyl chloride (58757-38-3) + Ethyl 2-phenylethanoate (101-97-3) → 3-(6-chloro-pyridin-3-yl)-3-oxo-2-phenyl-propionic acid ethyl ester (1026038-09-4)

Guidance literature:

Ethyl 2-phenylethanoate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

6-Chloronicotinoyl chloride; In tetrahydrofuran; for 1h;

DOI:10.1021/jm030327l

Reference yield:

3-(6-chloro-pyridin-3-yl)-3-oxo-2-phenyl-propionic acid ethyl ester (1026038-09-4) → 1-(6-chloropyridin-3-yl)-2-phenylethanone (634185-95-8)

Guidance literature:

With water; In dimethyl sulfoxide; at 155 ℃; for 3h;

DOI:10.1021/jm030327l

Reference yield:

3-(6-chloro-pyridin-3-yl)-3-oxo-2-phenyl-propionic acid ethyl ester (1026038-09-4) → 7-(6-dimethylamino-pyridin-3-yl)-5,6-diphenyl-pyrido[2,3-d]pyrimidin-4-ylamine

Guidance literature:

Multi-step reaction with 4 steps

1: 7.79 g / H₂O / dimethylsulfoxide / 3 h / 155 °C

2: ethanol / 18 h / Heating

3: NH₄OAc / butan-1-ol / 24 h / Heating

4: bis-(2-methoxy-ethyl) ether / 150 °C

With ammonium acetate; water; In ethanol; diethylene glycol dimethyl ether; dimethyl sulfoxide; butan-1-ol;

DOI:10.1021/jm030327l

upstream raw materials:

6-Chloronicotinoyl chloride

Ethyl 2-phenylethanoate

Downstream raw materials:

1-(6-chloropyridin-3-yl)-2-phenylethanone

1-(6-dimethylamino-pyridin-3-yl)-2-phenyl-ethanone

1-(6-morpholinopyridin-3-yl)-2-phenylethanone

6-amino-6'-dimethylamino-3,4-diphenyl-[2,3']bipyridinyl-5-carbonitrile