Technology Process of SX-633
There total 4 articles about SX-633 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C25H28BFN4O3;
With
potassium hydrogenfluoride;
In
methanol;
With
chloro-trimethyl-silane; water;
In
acetonitrile;
at 20 ℃;
for 1.5h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / N,N-dimethyl-formamide / 40 h / 20 °C / Inert atmosphere
2.1: triethylamine / N,N-dimethyl-formamide / 3 h / 130 °C / Inert atmosphere
3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 6.5 h / 80 °C / Inert atmosphere
4.1: potassium hydrogenfluoride / methanol
4.2: 1.5 h / 20 °C
With
potassium hydrogenfluoride; potassium acetate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
methanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / N,N-dimethyl-formamide / 40 h / 20 °C / Inert atmosphere
2.1: triethylamine / N,N-dimethyl-formamide / 3 h / 130 °C / Inert atmosphere
3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 6.5 h / 80 °C / Inert atmosphere
4.1: potassium hydrogenfluoride / methanol
4.2: 1.5 h / 20 °C
With
potassium hydrogenfluoride; potassium acetate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
methanol; N,N-dimethyl-formamide;
