bis(4-methoxyphenyl)-4-pyridylmethanol

Base Information

• Chemical Name: bis(4-methoxyphenyl)-4-pyridylmethanol
• CAS No.: 67916-57-8
• Molecular Formula: C₂₀H₁₉NO₃
• Molecular Weight: 321.376
• Mol file: 67916-57-8.mol

Synonyms:bis(4-methoxyphenyl)-4-pyridylmethanol

Chemical Property of bis(4-methoxyphenyl)-4-pyridylmethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of bis(4-methoxyphenyl)-4-pyridylmethanol

There total 4 articles about bis(4-methoxyphenyl)-4-pyridylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

pyridine-4-carbonitrile (100-48-1) + bis(p-methoxyphenyl)methanone (90-96-0) → bis(4-methoxyphenyl)-4-pyridylmethanol (67916-57-8)

Guidance literature:

pyridine-4-carbonitrile; With sodium; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

bis(p-methoxyphenyl)methanone; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.201200570

Reference yield: 85.0%

4-pyridinecarboxylic acid, methyl ester (2459-09-8) + 1-bromo-4-methoxy-benzene (104-92-7) → bis(4-methoxyphenyl)-4-pyridylmethanol (67916-57-8)

Guidance literature:

1-bromo-4-methoxy-benzene; With magnesium; In tetrahydrofuran; for 1h; Heating;

4-pyridinecarboxylic acid, methyl ester; In tetrahydrofuran; Further stages.;

DOI:10.1016/j.tet.2008.06.034

Reference yield:

isonicotinic acid ethylester (1570-45-2) + 1-bromo-4-methoxy-benzene (104-92-7) → bis(4-methoxyphenyl)-4-pyridylmethanol (67916-57-8)

Guidance literature:

With magnesium; Multistep reaction; 1) ether, 2) ether, rt;

upstream raw materials:

isonicotinic acid ethylester

1-bromo-4-methoxy-benzene

4-pyridinecarboxylic acid, methyl ester

pyridine-4-carbonitrile

Downstream raw materials:

4-[bis(4-methoxyphenyl)-4-pyridylmethyl]phenol

C₂₀H₁₈NO₂⁽¹⁺⁾

4-[(4-hydroxyphenyl)(N-methylpiperidin-4-ylidene)methyl]phenol

Acetic acid 4-[(4-acetoxy-phenyl)-(1-methyl-piperidin-4-ylidene)-methyl]-phenyl ester

Refernces

• 1、 Hatano, Tsukasa,Kato, Takashi. "Nanostructured columnar and cubic liquid-crystalline assemblies consisting of unconventional rigid mesogens based on triphenylmethanes". . p. 8368 - 8380. Retrieved 2008/12/21.