ethyl 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-piperidineacrylate

Base Information

Chemical Name:ethyl 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-piperidineacrylate
CAS No.:152875-93-9
Molecular Formula:C₂₅H₂₉F₂NO₃
Molecular Weight:429.507
Hs Code.:

Synonyms:ethyl 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-piperidineacrylate

Suppliers and Price of ethyl 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-piperidineacrylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-piperidineacrylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-piperidineacrylate

There total 11 articles about ethyl 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-piperidineacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50366-31-9
2-[bis(4-fluorophenyl)methoxy]ethyl chloride

: 152875-93-9
ethyl 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-piperidineacrylate

Guidance literature:: Multi-step reaction with 5 steps

1: 66 percent / Na₂CO₃, NaI / various solvent(s) / 9 h / Heating

2: 91 percent / (COCl)2, Et₃N, dimethylsulfoxide (DMSO) / CH₂Cl₂ / -60 - 20 °C

3: 1.) LDA / 1.) THF, -10 deg C, 30 min, 2.) THF, RT, 16 h

4: 59 percent / 10percent aq. HCl / tetrahydrofuran / 2 h / Ambient temperature

5: 1.) NaH / 1.) THF, 30 min, RT, 2.) THF, 1 h, RT

With hydrogenchloride; oxalyl dichloride; sodium hydride; sodium carbonate; dimethyl sulfoxide; triethylamine; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.41.882

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 152875-93-9
ethyl 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-piperidineacrylate

Guidance literature:: Multi-step reaction with 5 steps

1: 66 percent / Na₂CO₃, NaI / various solvent(s) / 9 h / Heating

2: 91 percent / (COCl)2, Et₃N, dimethylsulfoxide (DMSO) / CH₂Cl₂ / -60 - 20 °C

3: 1.) LDA / 1.) THF, -10 deg C, 30 min, 2.) THF, RT, 16 h

4: 59 percent / 10percent aq. HCl / tetrahydrofuran / 2 h / Ambient temperature

5: 1.) NaH / 1.) THF, 30 min, RT, 2.) THF, 1 h, RT

With hydrogenchloride; oxalyl dichloride; sodium hydride; sodium carbonate; dimethyl sulfoxide; triethylamine; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.41.882

Reference yield:

: 4395-98-6
4-cyanopiperidine

: 152875-93-9
ethyl 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-piperidineacrylate

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / Na₂CO₃, NaI / various solvent(s) / 17 h / Heating

2: 72 percent / DIBAL / hexane; tetrahydrofuran / 15 h / Ambient temperature

3: 1.) NaH / 1.) THF, 30 min, RT, 2.) THF, 1 h, RT

With sodium hydride; diisobutylaluminium hydride; sodium carbonate; sodium iodide; In tetrahydrofuran; hexane;
DOI:10.1248/cpb.41.882