ethyl (2E)-3-{5-chloro-6-methyl-4-oxo-3-[4-(4-trifluoromethoxy-phenoxy)-phenyl]-1,4-dihydro-pyridinyl}-2-propenoate

Base Information

Chemical Name:ethyl (2E)-3-{5-chloro-6-methyl-4-oxo-3-[4-(4-trifluoromethoxy-phenoxy)-phenyl]-1,4-dihydro-pyridinyl}-2-propenoate
CAS No.:958457-40-4
Molecular Formula:C₂₄H₁₉ClF₃NO₅
Molecular Weight:493.867
Hs Code.:

Synonyms:ethyl (2E)-3-{5-chloro-6-methyl-4-oxo-3-[4-(4-trifluoromethoxy-phenoxy)-phenyl]-1,4-dihydro-pyridinyl}-2-propenoate

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Chemical Property of ethyl (2E)-3-{5-chloro-6-methyl-4-oxo-3-[4-(4-trifluoromethoxy-phenoxy)-phenyl]-1,4-dihydro-pyridinyl}-2-propenoate

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Technology Process of ethyl (2E)-3-{5-chloro-6-methyl-4-oxo-3-[4-(4-trifluoromethoxy-phenoxy)-phenyl]-1,4-dihydro-pyridinyl}-2-propenoate

There total 12 articles about ethyl (2E)-3-{5-chloro-6-methyl-4-oxo-3-[4-(4-trifluoromethoxy-phenoxy)-phenyl]-1,4-dihydro-pyridinyl}-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 958457-38-0
5-chloro-6-methyl-4-oxo-3-[4-({4-[(trifluoromethyl)oxy]phenyl}oxy)phenyl]-1,4-dihydro-2-pydinecarbaldehyde

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 958457-40-4
ethyl (2E)-3-{5-chloro-6-methyl-4-oxo-3-[4-(4-trifluoromethoxy-phenoxy)-phenyl]-1,4-dihydro-pyridinyl}-2-propenoate

Guidance literature:: In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 873203-36-2
1-bromo-4-[4-(trifluoromethoxy)phenoxy]benzene

: 958457-40-4
ethyl (2E)-3-{5-chloro-6-methyl-4-oxo-3-[4-(4-trifluoromethoxy-phenoxy)-phenyl]-1,4-dihydro-pyridinyl}-2-propenoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium; Triisopropyl borate / tetrahydrofuran / 3 h / -75 °C

1.2: 18 h / 20 °C

2.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / ethanol; toluene / 2.45 h / 80 °C

3.1: ammonium hydroxide / ethanol; water / 8.5 h / 140 °C

4.1: trichloroisocyanuric acid / methanol; dichloromethane / 1.33 h / 0 °C

5.1: sulfur trioxide-pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 21 h / 0 - 20 °C

6.1: dichloromethane / 2 h / 20 °C

With ammonium hydroxide; n-butyllithium; sulfur trioxide-pyridine complex; Triisopropyl borate; trichloroisocyanuric acid; sodium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene;

Reference yield:

: 958457-26-6
3-hydroxy-6-methyl-2-(O-tert-butyldimethylsilyl)hydroxymethylpyran-4(1H)-one

: 958457-40-4
ethyl (2E)-3-{5-chloro-6-methyl-4-oxo-3-[4-(4-trifluoromethoxy-phenoxy)-phenyl]-1,4-dihydro-pyridinyl}-2-propenoate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1.67 h

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / ethanol; toluene / 2.45 h / 80 °C

3: ammonium hydroxide / ethanol; water / 8.5 h / 140 °C

4: trichloroisocyanuric acid / methanol; dichloromethane / 1.33 h / 0 °C

5: sulfur trioxide-pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 21 h / 0 - 20 °C

6: dichloromethane / 2 h / 20 °C

With ammonium hydroxide; sulfur trioxide-pyridine complex; trichloroisocyanuric acid; sodium carbonate; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;