Technology Process of 5-chloro-6-methyl-4-oxo-3-[4-({4-[(trifluoromethyl)oxy]phenyl}oxy)phenyl]-1,4-dihydro-2-pydinecarbaldehyde
There total 12 articles about 5-chloro-6-methyl-4-oxo-3-[4-({4-[(trifluoromethyl)oxy]phenyl}oxy)phenyl]-1,4-dihydro-2-pydinecarbaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2011.07.044
- Guidance literature:
-
Multi-step reaction with 4 steps
1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethanol; water; toluene / 80 °C
2: ammonia / ethanol; water / 140 °C
3: trichloroisocyanuric acid / methanol; dichloromethane / 0 - 20 °C
4: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0 - 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; trichloroisocyanuric acid; ammonia; sulfur trioxide pyridine complex; sodium carbonate; dimethyl sulfoxide; triethylamine;
In
methanol; ethanol; dichloromethane; water; toluene;
DOI:10.1016/j.bmcl.2011.07.044
- Guidance literature:
-
Multi-step reaction with 6 steps
1: palladium 10% on activated carbon; hydrogen / ethyl acetate
2: potassium carbonate / N,N-dimethyl-formamide / 20 °C
3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethanol; water; toluene / 80 °C
4: ammonia / ethanol; water / 140 °C
5: trichloroisocyanuric acid / methanol; dichloromethane / 0 - 20 °C
6: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0 - 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; trichloroisocyanuric acid; palladium 10% on activated carbon; ammonia; hydrogen; sulfur trioxide pyridine complex; sodium carbonate; potassium carbonate; dimethyl sulfoxide; triethylamine;
In
methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2011.07.044
