3-(4-fluorophenyl)-1-(4-(trifluoromethyl)phenyl)prop-2-yn-1-one

Base Information

• Chemical Name: 3-(4-fluorophenyl)-1-(4-(trifluoromethyl)phenyl)prop-2-yn-1-one
• CAS No.: 1428781-52-5
• Molecular Formula: C₁₆H₈F₄O
• Molecular Weight: 292.233
• Mol file: 1428781-52-5.mol

Synonyms:3-(4-fluorophenyl)-1-(4-(trifluoromethyl)phenyl)prop-2-yn-1-one

Chemical Property of 3-(4-fluorophenyl)-1-(4-(trifluoromethyl)phenyl)prop-2-yn-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-(4-fluorophenyl)-1-(4-(trifluoromethyl)phenyl)prop-2-yn-1-one

There total 3 articles about 3-(4-fluorophenyl)-1-(4-(trifluoromethyl)phenyl)prop-2-yn-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-ethynyl-4-fluorobenzene (766-98-3) + 4-trifluoromethyl-phenyl acetyl chloride (329-15-7) → 3-(4-fluorophenyl)-1-(4-(trifluoromethyl)phenyl)prop-2-yn-1-one (1428781-52-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; zinc(II) chloride; In neat (no solvent); at 20 ℃; for 0.5h;

DOI:10.1080/00397911.2012.745156

Reference yield: 72.0%

1-ethynyl-4-fluorobenzene (766-98-3) + 4-CF3C6H4CN (455-18-5) → 3-(4-fluorophenyl)-1-(4-(trifluoromethyl)phenyl)prop-2-yn-1-one (1428781-52-5)

Guidance literature:

1-ethynyl-4-fluorobenzene; 4-CF₃C₆H₄CN; With [(Me₃Si)₂N]₂Er([η¹:μ-η²-3-(2-(N-CH₃)C₄H₃NCH=N-CH₂-CH₂)C₈H₅N])(μ-Cl)Li(THF); In toluene; at 40 ℃; for 36h; Inert atmosphere; Schlenk technique;

With sulfuric acid; In water;

DOI:10.1007/s11426-014-5150-7

Reference yield:

C16H9F4N → 3-(4-fluorophenyl)-1-(4-(trifluoromethyl)phenyl)prop-2-yn-1-one (1428781-52-5)

Guidance literature:

With sulfuric acid; water; at 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1055/s-0033-1338446

upstream raw materials:

1-ethynyl-4-fluorobenzene

4-trifluoromethyl-phenyl acetyl chloride

4-CF₃C₆H₄CN

Downstream raw materials:

1-(4-fluoro-phenyl)-2-(4-trifluoromethyl-phenyl)-ethane-1,2-dione

(2-(4-fluorophenyl)benzofuran-3-yl)(4-(trifluoromethyl)phenyl)methanone