766-98-3

Basic information

• Product Name: 4-Fluorophenylacetylene
• Synonyms: (p-Fluorophenyl)acetylene;Benzene, 1-ethynyl-4-fluoro-;4'-FLUOROPHENYL ACETYLENE;4-FLUOROPHENYLACETYLENE;1-ETHYNYL-4-FLUOROBENZENE;1-ETHYNYL-4-FLUOROBENZENE 99%;1-ETHINYL-4-FLUOR-BENZOL;Benzene, 1-ethynyl-4-fluoro- (6CI, 7CI, 8CI, 9CI)
• CAS NO: 766-98-3
• Molecular Formula: C₈H₅F
• Molecular Weight: 120.12
• Product Categories: pharmacetical;Aromatics Compounds;Fluorine Compounds;Miscellaneous Compounds;Acetylenes;Acetylenic Hydrocarbons having Benzene Ring;Aromatics;Alkynyl;Halogenated Hydrocarbons;Organic Building Blocks
• Mol File: 766-98-3.mol
• Article Data: 46

Chemical Properties

• Melting Point: 26-27 °C(lit.)
• Boiling Point: 55-56 °C40 mm Hg(lit.)
• Flash Point: 29 °C
• Appearance: Clear colorless to yellow/Liquid After Melting
• Density: 1.048 g/mL at 25 °C(lit.)
• Vapor Pressure: 8.32mmHg at 25°C
• Refractive Index: n20/D 1.516(lit.)
• Storage Temp.: 2-8°C
• Water Solubility: Soluble in chloroform, diethyl ether, acetone, dichloromethane, hexane and ethanol. Highly soluble in toluene. Insoluble in wa
• BRN: 1099285
• CAS DataBase Reference: 4-Fluorophenylacetylene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluorophenylacetylene(766-98-3)
• EPA Substance Registry System: 4-Fluorophenylacetylene(766-98-3)

Safety Data

• Hazard Codes: F,Xi
• Statements: 36/37/38-11-10
• Safety Statements: 16-26-36-37/39
• RIDADR: UN 1325 4.1/PG 2
• WGK Germany: 3
• HazardClass: 4.1
• PackingGroup: II
• Hazardous Substances Data: 766-98-3(Hazardous Substances Data)

Usage

Chemical Properties

White Crystalline Solid

Uses

Different sources of media describe the Uses of 766-98-3 differently. You can refer to the following data:
1. Intermediates of liquid Crystals. As pharmaceutical intermediates. As organic synthesis intermediates. For vacuum deposition.
2. Intermediates of Liquid Crystals
3. 1-Ethynyl-4-fluorobenzene, a substituted phenylacetylene, may be used in the synthesis of aryl acetylenes, via Sonogashira type cross coupling reaction with various haloarenes in the presence of bis(μ-iodo)bis((-)-sparteine)dicopper(I) catalyst.

General Description

1-Ethynyl-4-fluorobenzene (pFAB) is a fluorobenzene derivative. Trianionic pincer alkylidyne complex catalyzed polymerization of 1-ethynyl-4-fluorobenzene has been reported. The surface of the iodophenyl-terminated organic monolayers has been modified by Sonogashira coupling of the iodophenyl groups found on the surface with pFAB. Dimerization catalyzed by Y[N(TMS)2]3 and 4-chloroaniline gave exclusive formation of one of three possible enediynes in excellent yield.

InChI:InChI=1/C8H5F/c1-2-7-3-5-8(9)6-4-7/h1,3-6H

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 1678-25-7 N-phenylbenzenesulfonamide 
• 87579-65-5 (C₆H₁₁)HgCCC₆H₄F 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 352-34-1 4-fluoro-1-iodobenzene 
• 471-25-0 Propiolic acid 
• 74-86-2 acetylene 
• 75-20-7 calcium carbide 
• 98-88-4 benzoyl chloride 
• 405-99-2 para-fluorostyrene 
• 66228-21-5 4-Fluor-α,α-dichlorethylbenzol 
• 130995-12-9 1-(4-fluorophenyl)-2-trimethylsilylacetylene 
• 108-98-5 thiophenol 
• 3246-80-8 9-phenyl-9H-xanthene 

Downstream Products

• 1737-34-4 1-(chloroethynyl)-4-fluorobenzene 
• 5157-58-4 2,2-dichloro-1-(4-fluorophenyl)-ethan-1-one 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 456-04-2 2-Chloro-4'-fluoroacetophenone 
• 87992-01-6 2-chloro-1-(4-fluorophenyl)butane-1,3-dione 
• 194936-20-4 2,3-Bis-[4-(4-fluoro-phenylethynyl)-phenyl]-quinoxaline 
• 194936-22-6 2,3-bis-[4-(4-fluoro-phenylethynyl)-phenyl]-quinoxaline-6-carboxylic acid 
• 405-29-8 (4-fluorophenyl)phenylacetylene 
• 58755-90-1 3-(4-fluorophenyl)-2,5-dihydrofuran-2,5-dione 
• 405065-66-9 4-para-fluorophenyl-3-butyn-2-one 

Relevant articles and documents

Photochemistry of 4-Substituted (Phenylethynyl)triphenylborate Salts: Analysis of the Visible-Region Electronic Absorption Spectra of Tetraarylboratirene Anions

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Synthesis and Photochemical Application of Hydrofluoroolefin (HFO) Based Fluoroalkyl Building Block

A novel fluoroalkyl iodide was synthesized on multigram scale from refrigerant gas HFO-1234yf as cheap industrial starting material in a simple, solvent-free, and easily scalable process. We demonstrated its applicability in a metal-free photocatalytic ATRA reaction to synthesize valuable fluoroalkylated vinyl iodides and proved the straightforward transformability of the products in cross-coupling chemistry to obtain conjugated systems.

BF3·OEt2-Promoted Propargyl Alcohol Rearrangement/[1,5]-Hydride Transfer/Cyclization Cascade Affording Tetrahydroquinolines

An efficient BF3·OEt2-mediated propargyl alcohol rearrangement/[1,5]-hydride transfer/cyclization cascade for the synthesis of tetrahydroquinoline derivatives has been described. The substituents adjacent to triple bonds play an important role in the formation of ketones (via [1,3]-hydroxyl shift) or alkenyl fluorides which are products of formal trans-carbofluorination of internal alkynes. This method provides a rapid access to diverse heterocycles in moderate to excellent yields.