17β(R)-<(β-phenylethyl)sulfinyl>-17α-chloro-1,4-androstadiene-3,11-dione

Base Information

Chemical Name:17β(R)-<(β-phenylethyl)sulfinyl>-17α-chloro-1,4-androstadiene-3,11-dione
CAS No.:73024-19-8
Molecular Formula:C₂₇H₃₁ClO₃S
Molecular Weight:471.06
Hs Code.:

Synonyms:17β(R)-<(β-phenylethyl)sulfinyl>-17α-chloro-1,4-androstadiene-3,11-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 17β(R)-<(β-phenylethyl)sulfinyl>-17α-chloro-1,4-androstadiene-3,11-dione

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Technology Process of 17β(R)-<(β-phenylethyl)sulfinyl>-17α-chloro-1,4-androstadiene-3,11-dione

There total 6 articles about 17β(R)-<(β-phenylethyl)sulfinyl>-17α-chloro-1,4-androstadiene-3,11-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 73024-09-6
17α-<(β-phenylethyl)thio>-1,4-androstadiene-3,11-dione

: 73024-19-8
17β(R)-<(β-phenylethyl)sulfinyl>-17α-chloro-1,4-androstadiene-3,11-dione

Guidance literature:: With pyridine; 1,2-Dichloro-3-iodobenzene; water; at -40 ℃; for 18h;
DOI:10.1021/jm00355a016

Reference yield:

: 2401-21-0
1,2-Dichloro-3-iodobenzene

: 73024-09-6
17α-<(β-phenylethyl)thio>-1,4-androstadiene-3,11-dione

: 73024-19-8
17β(R)-<(β-phenylethyl)sulfinyl>-17α-chloro-1,4-androstadiene-3,11-dione

Guidance literature:: With pyridine; In hexane; chloroform; water;

Reference yield:

: 7738-93-4
androsta-1,4-diene-3,11,17-trione

: 73024-19-8
17β(R)-<(β-phenylethyl)sulfinyl>-17α-chloro-1,4-androstadiene-3,11-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / NaBH₄ / methanol / 0.25 h / 0 - 5 °C

2: pyridine / 1 h / Ambient temperature

3: 22 percent / Na, EtOH / 48 h / Heating

4: 23 percent / iodobenzene dichloride, pyridine, H₂O / 18 h / -40 °C

With pyridine; sodium tetrahydroborate; ethanol; 1,2-Dichloro-3-iodobenzene; water; sodium; In methanol;
DOI:10.1021/jm00355a016