2401-21-0Relevant articles and documents
Oxidative halogenation of cisplatin and carboplatin: Synthesis, spectroscopy, and crystal and molecular structures of Pt(iv) prodrugs
Johnstone, Timothy C.,Alexander, Sarah M.,Wilson, Justin J.,Lippard, Stephen J.
, p. 119 - 129 (2015/02/02)
A series of Pt(iv) prodrugs has been obtained by oxidative halogenation of either cisplatin or carboplatin. Iodobenzene dichloride is a general reagent that cleanly provides prodrugs bearing axial chlorides without the need to prepare intervening Pt(iv) intermediates or handle chlorine gas. Elemental bromine and iodine afford Pt(iv) compounds as well, although in the case of the iodine-mediated oxidation of carboplatin, an amido-bridged Pt(iv) side product also formed. A detailed analysis of the changes in spectroscopic and structural parameters induced by varying the axial halide is presented. A number of recurring motifs are observed in the solid state structures of these compounds. This journal is
TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS
-
Page/Page column 41-42, (2012/09/10)
The present invention relates to tricyclic compounds of formula (I) or pharmaceutically acceptable salt thereof as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthama, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases. (I)
Regio- and chemoselective direct generation of functionalized aromatic aluminum compounds using aluminum ate base
Uchiyama, Masanobu,Naka, Hiroshi,Matsumoto, Yotaro,Ohwada, Tomohiko
, p. 10526 - 10527 (2007/10/03)
A regio- and chemoselective direct method for generation of functionalized aromatic aluminum compounds through deprotonative directed ortho-alumination using triisobutyl(tetramethylpiperidino)aluminate (iBu3Al(TMP)Li), prepared by mixing of triisobutylaluminum (iBu3Al) and lithium tetramethylpiperidide (LTMP) in THF, has been developed. Deprotonative alumination of various functionalized benzenes with the use of iBu3Al(TMP)Li proved effective for the direct generation of various ortho-functionalized aluminum aromatic and heteroaromatic derivatives, particularly those with electrophilic functional groups such as cyano, amide, and halogen. Direct alumination, followed by electrophilic trapping (with I2), provided a convenient preparative method for 1,2- or 1,2,3-multisubstituted aromatic compounds. The functionalized aromatic aluminate intermediate also was found to undergo copper- and palladium-catalyzed C-C bond-forming reactions very efficiently and highly regio- and chemoselectively. Copyright