3-butyl-2-phenylcyclopent-1-enyl t-butyldimethylsilyl ether

Base Information

• Chemical Name: 3-butyl-2-phenylcyclopent-1-enyl t-butyldimethylsilyl ether
• CAS No.: 1352617-30-1
• Molecular Formula: C₂₁H₃₄OSi
• Molecular Weight: 330.586
• Mol file: 1352617-30-1.mol

Synonyms:3-butyl-2-phenylcyclopent-1-enyl t-butyldimethylsilyl ether

Chemical Property of 3-butyl-2-phenylcyclopent-1-enyl t-butyldimethylsilyl ether

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 3-butyl-2-phenylcyclopent-1-enyl t-butyldimethylsilyl ether

There total 2 articles about 3-butyl-2-phenylcyclopent-1-enyl t-butyldimethylsilyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

n-butyl magnesium bromide (693-03-8) + 2-phenylcyclopent-2-enone (39545-99-8) + tert-butyldimethylsilyl chloride (18162-48-6) → 3-butyl-2-phenylcyclopent-1-enyl t-butyldimethylsilyl ether (1352617-30-1)

Guidance literature:

n-butyl magnesium bromide; With N,N,N,N,N,N-hexamethylphosphoric triamide; copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; at -78 ℃; for 0.5h;

2-phenylcyclopent-2-enone; tert-butyldimethylsilyl chloride; In tetrahydrofuran; at -78 ℃; for 2h;

With triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/ol2029417

Reference yield:

2-phenylcyclopent-1-enyl t-butyldimethylsilyl ether (1352617-29-8) → 3-butyl-2-phenylcyclopent-1-enyl t-butyldimethylsilyl ether (1352617-30-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: (x)BF₄*C₉H₁₄NO⁽¹⁺⁾ / dichloromethane / 1 h / -78 °C

1.2: 20 °C

2.1: N,N,N,N,N,N-hexamethylphosphoric triamide; copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.5 h / -78 °C

2.2: 2 h / -78 °C

2.3: 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; copper(I) bromide dimethylsulfide complex; (x)BF₄*C₉H₁₄NO⁽¹⁺⁾; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol2029417

Reference yield: 77.0%

3-butyl-2-phenylcyclopent-1-enyl t-butyldimethylsilyl ether (1352617-30-1) → 3-butyl-2-phenyl-2-cyclopenten-1-one

Guidance literature:

3-butyl-2-phenylcyclopent-1-enyl t-butyldimethylsilyl ether; With (x)BF₄*C₉H₁₄NO⁽¹⁺⁾; In dichloromethane; at -78 ℃; for 1h;

With sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃;

DOI:10.1021/ol2029417

upstream raw materials:

n-butyl magnesium bromide

2-phenylcyclopent-2-enone

tert-butyldimethylsilyl chloride

2-phenylcyclopent-1-enyl t-butyldimethylsilyl ether