(S)-2-Amino-3-[4-(3-benzyl-2-oxo-2,3-dihydro-imidazol-1-yl)-phenyl]-propionic acid

Base Information

• Chemical Name: (S)-2-Amino-3-[4-(3-benzyl-2-oxo-2,3-dihydro-imidazol-1-yl)-phenyl]-propionic acid
• CAS No.: 790208-55-8
• Molecular Formula: C₁₉H₁₉N₃O₃
• Molecular Weight: 337.378

Synonyms:(S)-2-Amino-3-[4-(3-benzyl-2-oxo-2,3-dihydro-imidazol-1-yl)-phenyl]-propionic acid

Chemical Property of (S)-2-Amino-3-[4-(3-benzyl-2-oxo-2,3-dihydro-imidazol-1-yl)-phenyl]-propionic acid

Chemical Property:

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Technology Process of (S)-2-Amino-3-[4-(3-benzyl-2-oxo-2,3-dihydro-imidazol-1-yl)-phenyl]-propionic acid

There total 3 articles about (S)-2-Amino-3-[4-(3-benzyl-2-oxo-2,3-dihydro-imidazol-1-yl)-phenyl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-[4-(3-benzyl-2-oxo-2,3-dihydro-imidazol-1-yl)-phenyl]-2-(9-phenyl-9H-fluoren-9-ylamino)-propionic acid tert-butyl ester (475474-07-8) → (S)-2-Amino-3-[4-(3-benzyl-2-oxo-2,3-dihydro-imidazol-1-yl)-phenyl]-propionic acid (790208-55-8)

Guidance literature:

With methoxybenzene; trifluoroacetic acid; In dichloromethane; at 25 ℃;

DOI:10.1016/S0960-894X(02)00210-X

Reference yield:

1-benzyl-1,3-dihydro-2H-imidazol-2-one (67909-04-0) → (S)-2-Amino-3-[4-(3-benzyl-2-oxo-2,3-dihydro-imidazol-1-yl)-phenyl]-propionic acid (790208-55-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / CuI; Cs₂CO₃ / dimethylformamide / 150 °C

2: 70 percent / TFA; anisole / CH₂Cl₂ / 25 °C

With copper(l) iodide; caesium carbonate; methoxybenzene; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Goldberg reaction;

DOI:10.1016/S0960-894X(02)00210-X

Reference yield:

3-(4-iodo-phenyl)-2-(9-phenyl-9H-fluoren-9-ylamino)-propionic acid tert-butyl ester → (S)-2-Amino-3-[4-(3-benzyl-2-oxo-2,3-dihydro-imidazol-1-yl)-phenyl]-propionic acid (790208-55-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / CuI; Cs₂CO₃ / dimethylformamide / 150 °C

2: 70 percent / TFA; anisole / CH₂Cl₂ / 25 °C

With copper(l) iodide; caesium carbonate; methoxybenzene; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Goldberg reaction;

DOI:10.1016/S0960-894X(02)00210-X

upstream raw materials:

3-[4-(3-benzyl-2-oxo-2,3-dihydro-imidazol-1-yl)-phenyl]-2-(9-phenyl-9H-fluoren-9-ylamino)-propionic acid tert-butyl ester

1-benzyl-1,3-dihydro-2H-imidazol-2-one

Downstream raw materials:

(S)-3-[4-(3-Benzyl-2-oxo-2,3-dihydro-imidazol-1-yl)-phenyl]-2-[((R)-2-methyl-tetrahydro-furan-2-carbonyl)-amino]-propionic acid methyl ester

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