(5S,6R,7R)-6,7-dihydroxy-5-hydroxymethyl-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione

Base Information

Chemical Name:(5S,6R,7R)-6,7-dihydroxy-5-hydroxymethyl-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione
CAS No.:1345970-37-7
Molecular Formula:C₁₃H₁₅N₃O₅
Molecular Weight:293.279
Hs Code.:

Synonyms:(5S,6R,7R)-6,7-dihydroxy-5-hydroxymethyl-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione

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Chemical Property of (5S,6R,7R)-6,7-dihydroxy-5-hydroxymethyl-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione

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Technology Process of (5S,6R,7R)-6,7-dihydroxy-5-hydroxymethyl-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione

There total 6 articles about (5S,6R,7R)-6,7-dihydroxy-5-hydroxymethyl-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1345970-34-4
(5S,6R,7R)-ethyl 6,7-dihydroxy-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione-5-carboxylate

: 1345970-37-7
(5S,6R,7R)-6,7-dihydroxy-5-hydroxymethyl-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 ℃; for 72h;
DOI:10.1021/jo201486q

Reference yield:

: 1345970-32-2
(5S,6R,7S)-ethyl 6,7-epoxy-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione-5-carboxylate

: 1345970-37-7
(5S,6R,7R)-6,7-dihydroxy-5-hydroxymethyl-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid; water / 8 h / Reflux

2: sodium tetrahydroborate / ethanol / 72 h / 20 °C

With sodium tetrahydroborate; sulfuric acid; water; In ethanol;
DOI:10.1021/jo201486q

Reference yield:

: 1345970-29-7
(5S,8S)-ethyl 8-(2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyloxy)-2-phenyl-2,4,9-triazabicyclo[4.3.0]non-6-ene-1,3-dione-5-carboxylate

: 1345970-37-7
(5S,6R,7R)-6,7-dihydroxy-5-hydroxymethyl-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1: triethylsilane; trifluoroacetic acid / dichloromethane / 5 h / 20 °C

2: oxone; sodium hydrogencarbonate / 1,1,1-trifluoro-2-propanone; water; acetonitrile / 22 h / 0 - 20 °C

3: sulfuric acid; water / 8 h / Reflux

4: sodium tetrahydroborate / ethanol / 72 h / 20 °C

With triethylsilane; sodium tetrahydroborate; oxone; sulfuric acid; water; sodium hydrogencarbonate; trifluoroacetic acid; In ethanol; dichloromethane; 1,1,1-trifluoro-2-propanone; water; acetonitrile;
DOI:10.1021/jo201486q