(5S,6R,7S)-ethyl 6,7-epoxy-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione-5-carboxylate

Base Information

• Chemical Name: (5S,6R,7S)-ethyl 6,7-epoxy-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione-5-carboxylate
• CAS No.: 1345970-32-2
• Molecular Formula: C₁₅H₁₅N₃O₅
• Molecular Weight: 317.301
• Mol file: 1345970-32-2.mol

Synonyms:(5S,6R,7S)-ethyl 6,7-epoxy-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione-5-carboxylate

Chemical Property of (5S,6R,7S)-ethyl 6,7-epoxy-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5S,6R,7S)-ethyl 6,7-epoxy-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione-5-carboxylate

There total 4 articles about (5S,6R,7S)-ethyl 6,7-epoxy-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(S)-ethyl 2-phenyl-2,4,9-triazabicyclo[4.3.0]non-6-ene-1,3-dione-5-carboxylate (1345970-30-0) → (5S,6S,7R)-ethyl 6,7-epoxy-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione-5-carboxylate + (5S,6R,7S)-ethyl 6,7-epoxy-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione-5-carboxylate (1345970-32-2)

Guidance literature:

With oxone; sodium hydrogencarbonate; In 1,1,1-trifluoro-2-propanone; water; acetonitrile; at 0 - 20 ℃; for 22h; optical yield given as %de;

DOI:10.1021/jo201486q

Reference yield:

(5S,8S)-ethyl 8-(2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyloxy)-2-phenyl-2,4,9-triazabicyclo[4.3.0]non-6-ene-1,3-dione-5-carboxylate (1345970-29-7) → (5S,6S,7R)-ethyl 6,7-epoxy-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione-5-carboxylate + (5S,6R,7S)-ethyl 6,7-epoxy-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione-5-carboxylate (1345970-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylsilane; trifluoroacetic acid / dichloromethane / 5 h / 20 °C

2: oxone; sodium hydrogencarbonate / 1,1,1-trifluoro-2-propanone; water; acetonitrile / 22 h / 0 - 20 °C

With triethylsilane; oxone; sodium hydrogencarbonate; trifluoroacetic acid; In dichloromethane; 1,1,1-trifluoro-2-propanone; water; acetonitrile;

DOI:10.1021/jo201486q

Reference yield:

4-Phenyl-1,2,4-triazolidine-3,5-dione (4233-33-4) → (5S,6S,7R)-ethyl 6,7-epoxy-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione-5-carboxylate + (5S,6R,7S)-ethyl 6,7-epoxy-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione-5-carboxylate (1345970-32-2)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 0.5 h

2: triethylsilane; trifluoroacetic acid / dichloromethane / 5 h / 20 °C

3: oxone; sodium hydrogencarbonate / 1,1,1-trifluoro-2-propanone; water; acetonitrile / 22 h / 0 - 20 °C

With triethylsilane; oxone; sodium hydrogencarbonate; trifluoroacetic acid; In dichloromethane; 1,1,1-trifluoro-2-propanone; water; acetonitrile; 1: Diels-Alder cycloaddition;

DOI:10.1021/jo201486q

upstream raw materials:

ethyl 5-(2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyloxy)-2,4-pentadienoate

(5S,8S)-ethyl 8-(2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyloxy)-2-phenyl-2,4,9-triazabicyclo[4.3.0]non-6-ene-1,3-dione-5-carboxylate

(S)-ethyl 2-phenyl-2,4,9-triazabicyclo[4.3.0]non-6-ene-1,3-dione-5-carboxylate

4-Phenyl-1,2,4-triazolidine-3,5-dione

Downstream raw materials:

(5S,6R,7R)-ethyl 6,7-dihydroxy-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione-5-carboxylate

(5S,6R,7R)-6,7-dihydroxy-5-hydroxymethyl-2-phenyl-2,4,9-triazabicyclo[4.3.0]nonane-1,3-dione

(4R,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-N-phenylhexahydropyridazine-1-carboxamide