4-[4-[(5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-1-methyl-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-2(1H)quinolinone

Base Information

Chemical Name:4-[4-[(5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-1-methyl-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-2(1H)quinolinone
CAS No.:700376-35-8
Molecular Formula:C₄₇H₄₀N₈O
Molecular Weight:732.888
Hs Code.:

Synonyms:4-[4-[(5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-1-methyl-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-2(1H)quinolinone

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Chemical Property of 4-[4-[(5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-1-methyl-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-2(1H)quinolinone

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Technology Process of 4-[4-[(5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-1-methyl-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-2(1H)quinolinone

There total 12 articles about 4-[4-[(5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-1-methyl-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-2(1H)quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133240-06-9
5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine

: 4-(4-bromomethyl-phenyl)-1-methyl-3-(2-trityl-2H-tetrazol-5-yl)-1H-quinolin-2-one

: 700376-35-8
4-[4-[(5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-1-methyl-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-2(1H)quinolinone

Guidance literature:: 5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;

4-(4-bromomethyl-phenyl)-1-methyl-3-(2-trityl-2H-tetrazol-5-yl)-1H-quinolin-2-one; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm031100t

Reference yield:

: 36192-63-9
2-amino-4'-methylbenzophenone

: 700376-35-8
4-[4-[(5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-1-methyl-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-2(1H)quinolinone

Guidance literature:: Multi-step reaction with 11 steps

1.1: CH₂Cl₂ / 1 h / 20 °C

2.1: NaH / ethanol / 2 h / Heating

3.1: tetrabutylammonium bromide; KOH / tetrahydrofuran; dimethylformamide / 0.17 h / 20 °C

3.2: 89 percent / tetrahydrofuran; dimethylformamide / 0.5 h / 20 °C

4.1: NaOH / ethanol / Heating

5.1: SOCl₂ / 1 h / Heating

6.1: NH₃ / CH₂Cl₂ / 0.67 h

7.1: 0.59 g / POCl₃ / benzene / 7 h / Heating

8.1: p-toluenesulfonic acid monohydrate; trimethylstannylazide / xylene / 115 - 120 °C

9.1: aq. NaOH / CH₂Cl₂; tetrahydrofuran / 0.25 h / 20 °C

9.2: tetrahydrofuran; CH₂Cl₂ / 3 h / 20 °C

10.1: N-bromosuccinimide; dibenzoyl peroxide / CCl₄ / Heating

11.1: NaH / dimethylformamide / 0.33 h / 0 °C

11.2: 0.18 g / dimethylformamide / 20 °C

With potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; thionyl chloride; tetrabutylammomium bromide; ammonia; sodium hydride; azidotrimethyltin; toluene-4-sulfonic acid; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide; xylene; benzene;
DOI:10.1021/jm031100t

Reference yield:

: 76-83-5
trityl chloride

: 700376-35-8
4-[4-[(5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-1-methyl-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-2(1H)quinolinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. NaOH / CH₂Cl₂; tetrahydrofuran / 0.25 h / 20 °C

1.2: tetrahydrofuran; CH₂Cl₂ / 3 h / 20 °C

2.1: N-bromosuccinimide; dibenzoyl peroxide / CCl₄ / Heating

3.1: NaH / dimethylformamide / 0.33 h / 0 °C

3.2: 0.18 g / dimethylformamide / 20 °C

With sodium hydroxide; N-Bromosuccinimide; sodium hydride; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm031100t