36192-63-9

Basic information

• Product Name: 2-AMINO-4'-METHYLBENZOPHENONE
• Synonyms: 2-AMINO-4'-METHYLBENZOPHENONE;TIMTEC-BB SBB005854;2-amino-4'-methylbenzophenone m;2-AMINO-4-METHYLBENZOPHENONE 99%;2-Amino-4'-methylbenzophenone,99%;(2-AMinophenyl)(p-tolyl)Methanone
• CAS NO: 36192-63-9
• Molecular Formula: C₁₄H₁₃NO
• Molecular Weight: 211.26
• EINECS: 252-905-7
• Product Categories: Aromatic Benzophenones & Derivatives (substituted)
• Mol File: 36192-63-9.mol
• Article Data: 36

Chemical Properties

• Melting Point: 91 °C
• Boiling Point: 350.95°C (rough estimate)
• Flash Point: 200°C
• Appearance: Yellow/Fine Crystalline Powder
• Density: 1.0694 (rough estimate)
• Refractive Index: 1.5780 (estimate)
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-AMINO-4'-METHYLBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4'-METHYLBENZOPHENONE(36192-63-9)
• EPA Substance Registry System: 2-AMINO-4'-METHYLBENZOPHENONE(36192-63-9)

Safety Data

• Hazardous Substances Data: 36192-63-9(Hazardous Substances Data)

Usage

Chemical Properties

YELLOW FINE CRYSTALLINE POWDER

Uses

2-Amino-4-methyl-benzophenone is used in the palladium-catalyzed preparation and antitumor activity of 2-aminobenzophenones, benzoyloxoindolines, and 7-benzoylindoles.

Upstream product

• 108-88-3 toluene 
• 380228-06-8 2-p-toluoyl-benzoic acid amide 
• 141368-26-5 2-N-(p-methylbenzenesulfonyl)amino-4'-methyl-benzophenone 
• 860543-84-6 3-(4'-methylphenyl)-3-hydroxy-1,3-dihydro-indol-2-one 
• 624-31-7 4-tolyl iodide 
• 1885-29-6 anthranilic acid nitrile 
• 5720-05-8 4-methylphenylboronic acid 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 201230-82-2 carbon monoxide 
• 615-43-0 2-iodophenylamine 
• 941-55-9 4-toluenesulfonyl azide 
• 134-84-9 4-Methylbenzophenone 
• 529-23-7 o-aminobenzaldehyde 
• 34999-55-8 (2-aminophenyl)(p-tolyl)methanol 

Downstream Products

• 106075-77-8 N-(2-p-toluoyl-phenyl)-phthalimide 
• 34999-55-8 (2-aminophenyl)(p-tolyl)methanol 
• 51570-53-7 2-amino-4'-methyldiphenylmethane 
• 64572-02-7 12-p-tolyl-isochromeno[3,4-b]quinolin-5-one 
• 113802-22-5 3-Aziridin-1-ylmethyl-4-p-tolyl-quinolin-2-ylamine 
• 113802-27-0 3-Piperidin-1-ylmethyl-4-p-tolyl-quinolin-2-ylamine 
• 500870-82-6 2-N-(4-aminosulfonylbenzoyl)-amide-4'-methyl-benzophenone 
• 149323-56-8 4-(4-methylphenyl)-3-quinolinecarboxylate 
• 37892-50-5 3-(4-methylphenyl)benzo[c]isoxazole 
• 1025506-21-1 4-(4-methylphenyl)-2,1,3-benzothiadiazine 2,2-dioxide 
• 16107-82-7 4-(4-methylphenyl)-2-phenyl-quinazoline 
• 1254354-84-1 5-fluoro-N-[2-(4-methylbenzoyl)phenyl]-1H-indole-2-carboxamide 
• 99933-64-9 4-(4'-methylphenyl)quinazoline 
• 853942-63-9 2,2,2-trichloro-N-[2-(4-methylbenzoyl)phenyl]acetamide 

Relevant articles and documents

One-Pot Synthesis of 2-Aminobenzophenones from 2-Alkynyl Arylazides Catalyzed by Pd and Cu Precursors

We describe a novel one-pot three-step reaction of 2-alkynyl arylazides through palladium-catalyzed formation of 3-hydroxy-3-phenylindolin-2-ones followed by hydrolysis of amide bonds and copper-catalyzed decarboxylation to give 2-aminobenzophenones. This synthetic method works well with various 2-alkynyl arylazides and affords the products in moderate to good yields under mild reaction conditions.

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration

An unprecedented deoxygenative arylation of aromatic carboxylic acids has been achieved, allowing the construction of an enhanced library of unsymmetrical diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chemistry allows for precise cleavage of a stronger C?O bond and formation of a weaker C?C bond by 1,5-aryl migration under mild reaction conditions. This new protocol is independent of substrate redox-potential, electronic, and substituent effects. It affords a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields.

Iron-Promoted Construction of Indoles via Intramolecular Oxidative C-N Coupling of 2-Alkenylanilines Using Persulfate

Indole scaffold synthesis relies primarily on oxidative C-H amination of N-protected alkenylanilines for C-N intramolecular cyclization reactions. Herein, for the first time, without N-protection, various readily prepared 2-alkenylanilines were transformed into the desired indole products in good yields by using K 2 S 2 O 8 as oxidant in the presence of catalytic amounts of FeF 2. The K 2 S 2 O 8 /FeF 2 system offers a direct and benign synthetic route to 3-arylindoles and it is applicable to a wide range of substituted indoles including drug intermediates.