1-((3Z)-4-(1-cyclohexyl-5-(4-methylthiophenyl)pyrazol-3-yl)but-3-enyloxy)-1,1,2,2-tetramethyl-1-silapropane

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Chemical Name:1-((3Z)-4-(1-cyclohexyl-5-(4-methylthiophenyl)pyrazol-3-yl)but-3-enyloxy)-1,1,2,2-tetramethyl-1-silapropane
CAS No.:641638-73-5
Molecular Formula:C₂₆H₄₀N₂OSSi
Molecular Weight:456.768
Hs Code.:

Synonyms:1-((3Z)-4-(1-cyclohexyl-5-(4-methylthiophenyl)pyrazol-3-yl)but-3-enyloxy)-1,1,2,2-tetramethyl-1-silapropane

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Chemical Property of 1-((3Z)-4-(1-cyclohexyl-5-(4-methylthiophenyl)pyrazol-3-yl)but-3-enyloxy)-1,1,2,2-tetramethyl-1-silapropane

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Technology Process of 1-((3Z)-4-(1-cyclohexyl-5-(4-methylthiophenyl)pyrazol-3-yl)but-3-enyloxy)-1,1,2,2-tetramethyl-1-silapropane

There total 5 articles about 1-((3Z)-4-(1-cyclohexyl-5-(4-methylthiophenyl)pyrazol-3-yl)but-3-enyloxy)-1,1,2,2-tetramethyl-1-silapropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 120379-76-2
[3-[(tert-butyldimethylsilyl)oxy]propyl]triphenylphosphonium bromide

: 641638-72-4
1-cyclohexyl-5-(4-methylthiophenyl)pyrazole-3-carbaldehyde

: 641638-73-5
1-((3Z)-4-(1-cyclohexyl-5-(4-methylthiophenyl)pyrazol-3-yl)but-3-enyloxy)-1,1,2,2-tetramethyl-1-silapropane

: 641638-74-6
1-((3E)-4-(1-cyclohexyl-5-(4-methylthiophenyl)pyrazol-3-yl)but-3-enyloxy)-1,1,2,2-tetramethyl-1-silapropane

Guidance literature:: [3-[(tert-butyldimethylsilyl)oxy]propyl]triphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

1-cyclohexyl-5-(4-methylthiophenyl)pyrazole-3-carbaldehyde; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1021/jm030276s

Reference yield:

: 1778-09-2
4-(Methylthio)acetophenone

: 641638-73-5
1-((3Z)-4-(1-cyclohexyl-5-(4-methylthiophenyl)pyrazol-3-yl)but-3-enyloxy)-1,1,2,2-tetramethyl-1-silapropane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 79 percent / sodium methoxide / toluene / 2 h / 20 °C

2.1: 85 percent / methanol / 70 °C

3.1: 95 percent / LiAlH₄ / tetrahydrofuran / 20 °C

4.1: 77 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 0 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

5.2: 61 percent / tetrahydrofuran; hexane / -78 - 20 °C

With lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; sodium methylate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene;
DOI:10.1021/jm030276s

Reference yield:

: 346684-15-9
methyl (2Z)-2-hydroxy-4-(4-methylthiophenyl)-4-oxobut-2-enoate

: 641638-73-5
1-((3Z)-4-(1-cyclohexyl-5-(4-methylthiophenyl)pyrazol-3-yl)but-3-enyloxy)-1,1,2,2-tetramethyl-1-silapropane

Guidance literature:: Multi-step reaction with 4 steps

1.1: 85 percent / methanol / 70 °C

2.1: 95 percent / LiAlH₄ / tetrahydrofuran / 20 °C

3.1: 77 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 0 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

4.2: 61 percent / tetrahydrofuran; hexane / -78 - 20 °C

With lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jm030276s