(S)-1-((1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethyl)-2-ethylaziridine

Base Information

Chemical Name:(S)-1-((1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethyl)-2-ethylaziridine
CAS No.:1429387-67-6
Molecular Formula:C₂₄H₃₃Cl₂NOSi
Molecular Weight:450.524
Hs Code.:

Synonyms:(S)-1-((1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethyl)-2-ethylaziridine

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Chemical Property of (S)-1-((1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethyl)-2-ethylaziridine

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Technology Process of (S)-1-((1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethyl)-2-ethylaziridine

There total 7 articles about (S)-1-((1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethyl)-2-ethylaziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1574555-38-6
(R)-1-(((1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethyl)amino)butan-2-ol

: 1429387-67-6
(S)-1-((1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethyl)-2-ethylaziridine

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 40 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm401767k

Reference yield:

: rac-(1R,2R)-2-amino-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol hydrochloride

: 1429387-67-6
(S)-1-((1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethyl)-2-ethylaziridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: 1H-imidazole / dichloromethane / 25 °C / Inert atmosphere

3.1: ytterbium(III) triflate / acetonitrile / 3 h / 130 °C / Microwave irradiation; Inert atmosphere

4.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 12 h / 40 °C / Inert atmosphere

With 1H-imidazole; triphenylphosphine; sodium hydroxide; ytterbium(III) triflate; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; acetonitrile; 4.1: |Mitsunobu Displacement;
DOI:10.1021/jm401767k

Reference yield:

: C₂₀H₂₅Cl₂NO₃Si

: 1429387-67-6
(S)-1-((1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethyl)-2-ethylaziridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; zinc / water / Inert atmosphere

2.1: sodium hydroxide / Inert atmosphere

2.2: Inert atmosphere; Reflux

3.1: 1H-imidazole / dichloromethane / 25 °C / Inert atmosphere

4.1: ytterbium(III) triflate / acetonitrile / 3 h / 130 °C / Microwave irradiation; Inert atmosphere

5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 12 h / 40 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; triphenylphosphine; sodium hydroxide; ytterbium(III) triflate; zinc; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; acetonitrile; 5.1: |Mitsunobu Displacement;
DOI:10.1021/jm401767k