(1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethanamine

Base Information

Chemical Name:(1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethanamine
CAS No.:1429387-88-1
Molecular Formula:C₂₀H₂₇Cl₂NOSi
Molecular Weight:396.432
Hs Code.:

Synonyms:(1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethanamine

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Chemical Property of (1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethanamine

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Technology Process of (1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethanamine

There total 5 articles about (1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1429382-53-5
(1R,2R)-2-amino-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1429387-88-1
(1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethanamine

Guidance literature:: With 1H-imidazole; In dichloromethane; at 25 ℃; Inert atmosphere;
DOI:10.1021/jm401767k

Reference yield:

: rac-(1R,2R)-2-amino-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol hydrochloride

: 1429387-88-1
(1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: 1H-imidazole / dichloromethane / 25 °C / Inert atmosphere

With 1H-imidazole; sodium hydroxide; In dichloromethane;
DOI:10.1021/jm401767k

Reference yield:

: C₂₀H₂₅Cl₂NO₃Si

: 1429387-88-1
(1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; zinc / water / Inert atmosphere

2.1: sodium hydroxide / Inert atmosphere

2.2: Inert atmosphere; Reflux

3.1: 1H-imidazole / dichloromethane / 25 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; sodium hydroxide; zinc; In dichloromethane; water;
DOI:10.1021/jm401767k