3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite>

Base Information

• Chemical Name: 3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite>
• CAS No.: 156046-18-3
• Molecular Formula: C₅₉H₇₁N₈O₁₂PSi
• Molecular Weight: 1143.32
• Mol file: 156046-18-3.mol

Synonyms:3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite>

Chemical Property of 3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite>

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite>

There total 4 articles about 3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

bis(N,N-diisopropylamino)-2-(4-nitrophenyl)ethoxyphosphane (108787-34-4) + 3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (112141-41-0) → 3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite> (156046-18-3)

Guidance literature:

With 1H-tetrazole; In acetonitrile; for 16h; Ambient temperature;

DOI:10.1002/hlca.19940770104

Reference yield:

2-(4-nitrophenyl)ethanol (100-27-6) → 3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite> (156046-18-3)

Guidance literature:

Multi-step reaction with 3 steps

1: PCl₃ / diethyl ether / 1.) -5 deg C, 15 min; 2.) r.t., 1.5 h;

2: diethyl ether / 1.) -10 deg C, 15 min; 2.) r.t., 16 h;

3: 92 percent / 1H-tetrazole / acetonitrile / 16 h / Ambient temperature

With 1H-tetrazole; phosphorus trichloride; In diethyl ether; acetonitrile;

DOI:10.1002/hlca.19940770104

Reference yield:

2-(4-nitrophenyl)ethyl chloride (20264-95-3) → 3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite> (156046-18-3)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 1.) -10 deg C, 15 min; 2.) r.t., 16 h;

2: 92 percent / 1H-tetrazole / acetonitrile / 16 h / Ambient temperature

With 1H-tetrazole; In diethyl ether; acetonitrile;

DOI:10.1002/hlca.19940770104

upstream raw materials:

bis(N,N-diisopropylamino)-2-(4-nitrophenyl)ethoxyphosphane

3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

2-(4-nitrophenyl)ethanol

2-(4-nitrophenyl)ethyl chloride