6-phenyl-5-(tetrahydrofuran-2-ylmethyl)-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile

Base Information

Chemical Name:6-phenyl-5-(tetrahydrofuran-2-ylmethyl)-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile
CAS No.:1379792-79-6
Molecular Formula:C₁₉H₁₅N₅O
Molecular Weight:329.361
Hs Code.:

Synonyms:6-phenyl-5-(tetrahydrofuran-2-ylmethyl)-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile

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Chemical Property of 6-phenyl-5-(tetrahydrofuran-2-ylmethyl)-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile

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Technology Process of 6-phenyl-5-(tetrahydrofuran-2-ylmethyl)-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile

There total 3 articles about 6-phenyl-5-(tetrahydrofuran-2-ylmethyl)-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1379792-74-1
C₁₁H₁₀ClN₅O

: 536-74-3
phenylacetylene

: 1379792-79-6
6-phenyl-5-(tetrahydrofuran-2-ylmethyl)-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium dodecyl-sulfate; potassium carbonate; In water; at 70 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.04.016

Reference yield:

: 56413-95-7
2,3-dichloro-5,6-dicyanopyrazine

: 1379792-79-6
6-phenyl-5-(tetrahydrofuran-2-ylmethyl)-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; sodium dodecyl-sulfate; potassium carbonate / water / 24 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium dodecyl-sulfate; potassium carbonate; In tetrahydrofuran; water; 2: Sonogashira coupling/cyclization;
DOI:10.1016/j.tetlet.2012.04.016

Reference yield:

: 36023-64-0
2,3-dioxo-1,2,3,4-tetrahydropyrazine-5,6-dicarbonitrile

: 1379792-79-6
6-phenyl-5-(tetrahydrofuran-2-ylmethyl)-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride

2: tetrahydrofuran

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; sodium dodecyl-sulfate; potassium carbonate / water / 24 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; thionyl chloride; sodium dodecyl-sulfate; potassium carbonate; In tetrahydrofuran; water; 3: Sonogashira coupling/cyclization;
DOI:10.1016/j.tetlet.2012.04.016