1,4,5,6-TETRAHYDRO-5,6-DIOXO-2,3-PYRAZINEDICARBONITRILE

Base Information

• Chemical Name: 1,4,5,6-TETRAHYDRO-5,6-DIOXO-2,3-PYRAZINEDICARBONITRILE
• CAS No.: 36023-64-0
• Molecular Formula: C6H2 N4 O2
• Molecular Weight: 162.107
• Hs Code.: 2933990090
• Mol file: 36023-64-0.mol

Synonyms:1,4,5,6-Tetrahydro-5,6-dioxo-2,3-pyrazinedicarbonitrile;2,3-Dioxo-1,2,3,4-tetrahydropyrazine-5,6-dicarbonitrile;5,6-Dioxo-1,4,5,6-tetrahydro-2,3-pyrazinedicarbonitrile

Chemical Property of 1,4,5,6-TETRAHYDRO-5,6-DIOXO-2,3-PYRAZINEDICARBONITRILE

Chemical Property:

• PKA: 3.56±0.60(Predicted)
• PSA: 113.30000
• Density: 1.62g/cm3
• LogP: -1.19344
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: almost transparency in hot Water

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,4,5,6-Tetrahydro-5,6-dioxo-2,3-pyrazinedicarbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4,5,6-TETRAHYDRO-5,6-DIOXO-2,3-PYRAZINEDICARBONITRILE

There total 3 articles about 1,4,5,6-TETRAHYDRO-5,6-DIOXO-2,3-PYRAZINEDICARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

oxalyl dichloride (79-37-8) + diaminomaleonitrile (1187-42-4) → 2,3-dioxo-1,2,3,4-tetrahydropyrazine-5,6-dicarbonitrile (36023-64-0)

Guidance literature:

In 1,4-dioxane; 1.) room temperature, 1 h, 2.) 50 deg C, 4 h;;

Reference yield: 85.0%

oxalyl dichloride (79-37-8) + 2,3-diaminomaleonitrile (18514-52-8) → 2,3-dioxo-1,2,3,4-tetrahydropyrazine-5,6-dicarbonitrile (36023-64-0)

Guidance literature:

With 1,4-dioxane; In 1,4-dioxane; at 50 ℃; Cooling with ice; Inert atmosphere; Sealed tube;

Reference yield:

→ 2,3-dioxo-1,2,3,4-tetrahydropyrazine-5,6-dicarbonitrile (36023-64-0)

Guidance literature:

Oxalylcyanid, DMMN (daneben 11);

DOI:10.1021/jo00923a016

upstream raw materials:

oxalyl dichloride

diaminomaleonitrile

2,3-diaminomaleonitrile

Downstream raw materials:

C₁₂H₅Cl₂N₅

5-benzyl-6-phenyl-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile

5-(benzylamino)-6-(phenylethynyl)pyrazine-2,3-dicarbonitrile

5-(2-methoxyethyl)-6-phenyl-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile

Refernces

• 1、 -. "Imidazopyrazine organic compound and application thereof". Paragraph 0173-0176. . Retrieved 2021/03/30.
• 2、 Keivanloo, Ali,Bakherad, Mohammad,Nasr-Isfahani, Hossein,Esmaily, Somayeh. "Highly efficient synthesis of 5,6-disubstituted-5H-pyrrolo[2,3-b]pyrazine- 2,3-dicarbonitriles through a one-pot palladium-catalyzed coupling reaction/cyclization in water". scheme or table. p. 3126 - 3130. Retrieved 2012/08/08.