trans-ethyl 4-((1-(5-(5-fluoro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

Base Information

Chemical Name:trans-ethyl 4-((1-(5-(5-fluoro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate
CAS No.:1415571-51-5
Molecular Formula:C₂₆H₃₁FN₄O₃
Molecular Weight:466.556
Hs Code.:

Synonyms:trans-ethyl 4-((1-(5-(5-fluoro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

Suppliers and Price of trans-ethyl 4-((1-(5-(5-fluoro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trans-ethyl 4-((1-(5-(5-fluoro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trans-ethyl 4-((1-(5-(5-fluoro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

There total 6 articles about trans-ethyl 4-((1-(5-(5-fluoro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 367-31-7
4-fluoro-1,2-phenylenediamine

: 1415573-51-1
trans-ethyl 4-((1-(5-formylpyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

: 1415571-51-5
trans-ethyl 4-((1-(5-(5-fluoro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

Guidance literature:: With Oxone; In N,N-dimethyl acetamide; water; at 20 ℃; for 2h;
DOI:10.1021/ml5003426

Reference yield:

: 1415573-46-4
trans-ethyl 4-(pyridin-4-yloxy)cyclohexanecarboxylate

: 1415571-51-5
trans-ethyl 4-((1-(5-(5-fluoro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: platinum(IV) oxide; toluene-4-sulfonic acid; hydrogen / ethanol / 120 h / 20 °C / 2327.23 Torr / Inert atmosphere

2: sodium hydrogencarbonate / dimethyl sulfoxide / 110 °C

3: Oxone / N,N-dimethyl acetamide; water / 2 h / 20 °C

With platinum(IV) oxide; Oxone; hydrogen; sodium hydrogencarbonate; toluene-4-sulfonic acid; In ethanol; N,N-dimethyl acetamide; water; dimethyl sulfoxide;
DOI:10.1021/ml5003426

Reference yield:

: 677728-92-6
2-fluoro-5-formylpyridine

: 1415571-51-5
trans-ethyl 4-((1-(5-(5-fluoro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / dimethyl sulfoxide / 110 °C

2: Oxone / N,N-dimethyl acetamide; water / 2 h / 20 °C

With Oxone; sodium hydrogencarbonate; In N,N-dimethyl acetamide; water; dimethyl sulfoxide;
DOI:10.1021/ml5003426