(3'R,4a'S,8a'R)-6'-(4-(benzyloxy)butyl)-3'-methyl-3',4',4a',5',8',8a'-hexahydro-2'H-spiro[[1,3]dioxolane-2,1'-naphthalene]

Base Information

Chemical Name:(3'R,4a'S,8a'R)-6'-(4-(benzyloxy)butyl)-3'-methyl-3',4',4a',5',8',8a'-hexahydro-2'H-spiro[[1,3]dioxolane-2,1'-naphthalene]
CAS No.:1052101-17-3
Molecular Formula:C₂₄H₃₄O₃
Molecular Weight:370.532
Hs Code.:

Synonyms:(3'R,4a'S,8a'R)-6'-(4-(benzyloxy)butyl)-3'-methyl-3',4',4a',5',8',8a'-hexahydro-2'H-spiro[[1,3]dioxolane-2,1'-naphthalene]

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Chemical Property of (3'R,4a'S,8a'R)-6'-(4-(benzyloxy)butyl)-3'-methyl-3',4',4a',5',8',8a'-hexahydro-2'H-spiro[[1,3]dioxolane-2,1'-naphthalene]

Chemical Property:

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Technology Process of (3'R,4a'S,8a'R)-6'-(4-(benzyloxy)butyl)-3'-methyl-3',4',4a',5',8',8a'-hexahydro-2'H-spiro[[1,3]dioxolane-2,1'-naphthalene]

There total 5 articles about (3'R,4a'S,8a'R)-6'-(4-(benzyloxy)butyl)-3'-methyl-3',4',4a',5',8',8a'-hexahydro-2'H-spiro[[1,3]dioxolane-2,1'-naphthalene] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 7381-30-8
2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane

: (((4-methylenehex-5-en-1-yl)oxy)methyl)benzene

: 54307-74-3,15466-88-3
(R)-5-methyl-cyclohex-2-enone

: 1052101-17-3
(3'R,4a'S,8a'R)-6'-(4-(benzyloxy)butyl)-3'-methyl-3',4',4a',5',8',8a'-hexahydro-2'H-spiro[[1,3]dioxolane-2,1'-naphthalene]

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -78 ℃; for 22h;
DOI:10.1021/ja804624u

Reference yield: 64.0%

: 7381-30-8
2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane

: 54307-74-3,15466-88-3
(R)-5-methyl-cyclohex-2-enone

: 1052101-15-1
((5-methylenehept-6-enyloxy)methyl)benzene

: 1052101-17-3
(3'R,4a'S,8a'R)-6'-(4-(benzyloxy)butyl)-3'-methyl-3',4',4a',5',8',8a'-hexahydro-2'H-spiro[[1,3]dioxolane-2,1'-naphthalene]

Guidance literature:: 2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane; (R)-5-methyl-cyclohex-2-enone; With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -78 ℃; for 0.0833333h; Inert atmosphere;

((5-methylenehept-6-enyloxy)methyl)benzene; In dichloromethane; at -78 ℃; for 22h; Inert atmosphere;
DOI:10.1021/jo101619d

Reference yield:

: 928-90-5
5-hexyl-1-ol

: 1052101-17-3
(3'R,4a'S,8a'R)-6'-(4-(benzyloxy)butyl)-3'-methyl-3',4',4a',5',8',8a'-hexahydro-2'H-spiro[[1,3]dioxolane-2,1'-naphthalene]

Guidance literature:: Multi-step reaction with 3 steps

1: tetra-(n-butyl)ammonium iodide; potassium hydride / tetrahydrofuran / 0 - 20 °C

2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 4 h / 25 °C / 15514.9 Torr / Inert atmosphere

3: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 22 h / -78 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; trimethylsilyl trifluoromethanesulfonate; tetra-(n-butyl)ammonium iodide; potassium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja804624u