N'-((1S,3R,4aS,8aR)-6-(4-(benzyloxy)butyl)-3-methyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-1-yl)benzohydrazide

Base Information

Chemical Name:N'-((1S,3R,4aS,8aR)-6-(4-(benzyloxy)butyl)-3-methyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-1-yl)benzohydrazide
CAS No.:1052101-21-9
Molecular Formula:C₂₉H₃₈N₂O₂
Molecular Weight:446.633
Hs Code.:

Synonyms:N'-((1S,3R,4aS,8aR)-6-(4-(benzyloxy)butyl)-3-methyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-1-yl)benzohydrazide

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Chemical Property of N'-((1S,3R,4aS,8aR)-6-(4-(benzyloxy)butyl)-3-methyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-1-yl)benzohydrazide

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Technology Process of N'-((1S,3R,4aS,8aR)-6-(4-(benzyloxy)butyl)-3-methyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-1-yl)benzohydrazide

There total 7 articles about N'-((1S,3R,4aS,8aR)-6-(4-(benzyloxy)butyl)-3-methyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-1-yl)benzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₆N₂O₂

: 1052101-21-9
N'-((1S,3R,4aS,8aR)-6-(4-(benzyloxy)butyl)-3-methyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-1-yl)benzohydrazide

Guidance literature:: C₂₉H₃₆N₂O₂; With hydrogenchloride; sodium cyanoborohydride; In methanol; water; at 25 ℃; for 1h; pH=Ca. 3 - 5; Inert atmosphere;

With potassium hydroxide; In methanol; water; at 25 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jo101619d

Reference yield:

: 928-90-5
5-hexyl-1-ol

: 1052101-21-9
N'-((1S,3R,4aS,8aR)-6-(4-(benzyloxy)butyl)-3-methyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-1-yl)benzohydrazide

Guidance literature:: Multi-step reaction with 6 steps

1: tetra-(n-butyl)ammonium iodide; potassium hydride / tetrahydrofuran / 0 - 20 °C

2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 4 h / 25 °C / 15514.9 Torr / Inert atmosphere

3: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 22 h / -78 °C

4: FeCl₃ adsorbed on silica gel / acetone / 2 h / 25 °C

5: methanol / 72 h / 25 °C

6: hydrogenchloride; sodium cyanoborohydride / methanol / 0.5 h / 25 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; hydrogenchloride; trimethylsilyl trifluoromethanesulfonate; tetra-(n-butyl)ammonium iodide; potassium hydride; sodium cyanoborohydride; In tetrahydrofuran; methanol; dichloromethane; acetone;
DOI:10.1021/ja804624u

Reference yield:

: 1052101-19-5
(3R,4aS,8aR)-6-(4-(benzyloxy)butyl)-3-methyl-3,4,4a,5,8,8a-hexahydronaphthalen-1(2H)-one

: 1052101-21-9
N'-((1S,3R,4aS,8aR)-6-(4-(benzyloxy)butyl)-3-methyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-1-yl)benzohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 72 h / 25 °C

2: hydrogenchloride; sodium cyanoborohydride / methanol / 0.5 h / 25 °C

With hydrogenchloride; sodium cyanoborohydride; In methanol;
DOI:10.1021/ja804624u