N-(2-methyl-4-methoxy-2H-1,2-benzothiazine-3-carbonyl)-L-phenylalaninol 1,1-dioxide

Base Information

• Chemical Name: N-(2-methyl-4-methoxy-2H-1,2-benzothiazine-3-carbonyl)-L-phenylalaninol 1,1-dioxide
• CAS No.: 208051-74-5
• Molecular Formula: C₂₀H₂₂N₂O₅S
• Molecular Weight: 402.471
• Mol file: 208051-74-5.mol

Synonyms:N-(2-methyl-4-methoxy-2H-1,2-benzothiazine-3-carbonyl)-L-phenylalaninol 1,1-dioxide

Chemical Property of N-(2-methyl-4-methoxy-2H-1,2-benzothiazine-3-carbonyl)-L-phenylalaninol 1,1-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-methyl-4-methoxy-2H-1,2-benzothiazine-3-carbonyl)-L-phenylalaninol 1,1-dioxide

There total 3 articles about N-(2-methyl-4-methoxy-2H-1,2-benzothiazine-3-carbonyl)-L-phenylalaninol 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

L-Phenylalaninol (3182-95-4) + 2-methyl-4-methoxy-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide (208051-70-1) → N-(2-methyl-4-methoxy-2H-1,2-benzothiazine-3-carbonyl)-L-phenylalaninol 1,1-dioxide (208051-74-5)

Guidance literature:

With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol;

DOI:10.1021/jm010178b

Reference yield:

methyl 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (35511-15-0) → N-(2-methyl-4-methoxy-2H-1,2-benzothiazine-3-carbonyl)-L-phenylalaninol 1,1-dioxide (208051-74-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 54 percent / K₂CO₃ / acetone / 40 h / Heating

2: 5 N aq. NaOH / methanol / 0.33 h / 20 °C

3: 99 percent / BOP; HOBt; NMM

With 4-methyl-morpholine; sodium hydroxide; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; In methanol; acetone;

DOI:10.1021/jm010178b

Reference yield:

methyl 4-methoxy-2-methyl-2H-benzo[e][1,2]thiazine-3-carboxylate-1,1-dioxide (208051-67-6) → N-(2-methyl-4-methoxy-2H-1,2-benzothiazine-3-carbonyl)-L-phenylalaninol 1,1-dioxide (208051-74-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 5 N aq. NaOH / methanol / 0.33 h / 20 °C

2: 99 percent / BOP; HOBt; NMM

With 4-methyl-morpholine; sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; In methanol;

DOI:10.1021/jm010178b

upstream raw materials:

L-Phenylalaninol

2-methyl-4-methoxy-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide

methyl 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

methyl 4-methoxy-2-methyl-2H-benzo[e][1,2]thiazine-3-carboxylate-1,1-dioxide