2-METHYL-4-HYDROXY-2H-1,2-BENZOTHIAZINE-3-CARBOXYLIC METHYL ESTER-1,1-DIOXIDE

Base Information

• Chemical Name: 2-METHYL-4-HYDROXY-2H-1,2-BENZOTHIAZINE-3-CARBOXYLIC METHYL ESTER-1,1-DIOXIDE
• CAS No.: 35511-15-0
• Molecular Formula: C11H11NO5S
• Molecular Weight: 269.278
• Hs Code.: 2934991000
• Mol file: 35511-15-0.mol

Synonyms:2-Methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylicacid methyl ester 1,1-dioxide;4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid methyl ester1,1-dioxide;

Chemical Property of 2-METHYL-4-HYDROXY-2H-1,2-BENZOTHIAZINE-3-CARBOXYLIC METHYL ESTER-1,1-DIOXIDE

Chemical Property:

• Appearance/Colour: Off-white to pale yellow solid
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 163-165 °C
• Refractive Index: 1.632
• Boiling Point: 439.9 °C at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 219.8 °C
• PSA: 92.29000
• Density: 1.515 g/cm³
• LogP: 1.73900
• Storage Temp.: -20?C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Piroxicam Impurity J. It Is also an impurity found in Meloxicam (M216100). Methyl 4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-Dioxide (Piroxicam EP Impurity J) is an impurity found in Meloxicam (M216100).

Technology Process of 2-METHYL-4-HYDROXY-2H-1,2-BENZOTHIAZINE-3-CARBOXYLIC METHYL ESTER-1,1-DIOXIDE

There total 19 articles about 2-METHYL-4-HYDROXY-2H-1,2-BENZOTHIAZINE-3-CARBOXYLIC METHYL ESTER-1,1-DIOXIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (35511-14-9) + methyl iodide (74-88-4) → methyl 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (35511-15-0)

Guidance literature:

With potassium hydroxide; N-butylpyridinium tetrafluoroborate; at 40 ℃; for 6h;

DOI:10.1248/cpb.54.1175

Reference yield: 91.0%

methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (35511-14-9) + dimethyl sulfate (77-78-1) → methyl 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (35511-15-0)

Guidance literature:

methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide; With sodium hydroxide; In water; acetone; at 20 ℃; for 0.0833333h;

dimethyl sulfate; In water; acetone; for 0.583333h;

With hydrogenchloride; In water; acetone;

DOI:10.1016/j.ejmech.2011.03.020

Reference yield: 87.0%

methyl 2-(N-methyl-N-(methoxycarbonylmethyl)sulfamoyl)benzoate (113412-07-0) → methyl 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (35511-15-0)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 5.5h;

upstream raw materials:

N-methylsaccharin

methyl chloroacetate

methyl 3-oxo-2,3-dihydrobenzo[d][1,2]thiazol-2-acetate 1,1-dioxide

sodium methylate

Downstream raw materials:

sudoxicam

isoxicam

meloxicam

Piroxicam