4-methyl-N-(1-methyl-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indol-2-yl)benzenesulfonamide

Base Information

• Chemical Name: 4-methyl-N-(1-methyl-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indol-2-yl)benzenesulfonamide
• CAS No.: 1562571-62-3
• Molecular Formula: C₂₄H₂₂N₄O₂S
• Molecular Weight: 430.53

Synonyms:4-methyl-N-(1-methyl-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indol-2-yl)benzenesulfonamide

Chemical Property of 4-methyl-N-(1-methyl-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indol-2-yl)benzenesulfonamide

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Technology Process of 4-methyl-N-(1-methyl-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indol-2-yl)benzenesulfonamide

There total 3 articles about 4-methyl-N-(1-methyl-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indol-2-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-methyl-3-tosyl-3,4-dihydro-[1,2,3]triazolo[4,5-b]indole (1562569-28-1) + 1-methyl-1H-pyrrolo[2,3-b]pyridine (27257-15-4) → 4-methyl-N-(1-methyl-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indol-2-yl)benzenesulfonamide (1562571-62-3)

Guidance literature:

With rhodium (II) octanoate dimer; In toluene; at 80 ℃; regioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/ol5002347

Reference yield:

4-toluenesulfonyl azide (941-55-9) → 4-methyl-N-(1-methyl-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indol-2-yl)benzenesulfonamide (1562571-62-3)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) chloride; triethylamine / acetonitrile / 3 h / 20 °C / Inert atmosphere; Schlenk technique

2: rhodium (II) octanoate dimer / toluene / 80 °C / Inert atmosphere; Schlenk technique

With rhodium (II) octanoate dimer; triethylamine; copper(l) chloride; In toluene; acetonitrile;

DOI:10.1021/ol5002347

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 4-methyl-N-(1-methyl-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indol-2-yl)benzenesulfonamide (1562571-62-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide / ethanol; water / 3 h / 20 °C / Heating

2: copper(l) chloride; triethylamine / acetonitrile / 3 h / 20 °C / Inert atmosphere; Schlenk technique

3: rhodium (II) octanoate dimer / toluene / 80 °C / Inert atmosphere; Schlenk technique

With sodium azide; rhodium (II) octanoate dimer; triethylamine; copper(l) chloride; In ethanol; water; toluene; acetonitrile;

DOI:10.1021/ol5002347

upstream raw materials:

4-toluenesulfonyl azide

p-toluenesulfonyl chloride

4-methyl-3-tosyl-3,4-dihydro-[1,2,3]triazolo[4,5-b]indole

1-methyl-1H-pyrrolo[2,3-b]pyridine

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