diisopropyl (R)-({[1-fluoro-3-(tosyloxy)propan-2-yl]oxy}methyl)phosphonate

Base Information

Chemical Name:diisopropyl (R)-({[1-fluoro-3-(tosyloxy)propan-2-yl]oxy}methyl)phosphonate
CAS No.:146459-57-6
Molecular Formula:C₁₇H₂₈FO₇PS
Molecular Weight:426.443
Hs Code.:

Synonyms:diisopropyl (R)-({[1-fluoro-3-(tosyloxy)propan-2-yl]oxy}methyl)phosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diisopropyl (R)-({[1-fluoro-3-(tosyloxy)propan-2-yl]oxy}methyl)phosphonate

Chemical Property:

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Technology Process of diisopropyl (R)-({[1-fluoro-3-(tosyloxy)propan-2-yl]oxy}methyl)phosphonate

There total 9 articles about diisopropyl (R)-({[1-fluoro-3-(tosyloxy)propan-2-yl]oxy}methyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1305351-57-8
diisopropyl (R)-{[(1-fluoro-3-hydroxypropan-2-yl)oxy]methyl}phosphonate

: 98-59-9
p-toluenesulfonyl chloride

: 146459-57-6
diisopropyl (R)-({[1-fluoro-3-(tosyloxy)propan-2-yl]oxy}methyl)phosphonate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.bmc.2011.02.050

Reference yield:

: 1305351-55-6
diisopropyl (R)-({[1-fluoro-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate

: 146459-57-6
diisopropyl (R)-({[1-fluoro-3-(tosyloxy)propan-2-yl]oxy}methyl)phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: water; acetic acid / 0.5 h / 90 °C

2: dmap; triethylamine / dichloromethane / 2 h / 0 - 20 °C

With dmap; water; acetic acid; triethylamine; In dichloromethane;
DOI:10.1016/j.bmc.2011.02.050

Reference yield:

: 35717-98-7
bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate

: 146459-57-6
diisopropyl (R)-({[1-fluoro-3-(tosyloxy)propan-2-yl]oxy}methyl)phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / -20 °C / Inert atmosphere

1.2: 20 °C

2.1: water; acetic acid / 0.5 h / 90 °C

3.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 20 °C

With dmap; water; sodium hydride; acetic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2011.02.050