diisopropyl (R)-({[1-fluoro-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate

Base Information

Chemical Name:diisopropyl (R)-({[1-fluoro-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate
CAS No.:1305351-55-6
Molecular Formula:C₂₉H₃₆FO₅P
Molecular Weight:514.574
Hs Code.:

Synonyms:diisopropyl (R)-({[1-fluoro-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diisopropyl (R)-({[1-fluoro-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate

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Technology Process of diisopropyl (R)-({[1-fluoro-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate

There total 3 articles about diisopropyl (R)-({[1-fluoro-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 98432-80-5
diisopropyl (bromomethyl)phosphonate

: 142631-77-4
(+)-(2R)-1-fluoro-3-(triphenylmethoxy)propan-2-ol

: 1305351-55-6
diisopropyl (R)-({[1-fluoro-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at -20 - 20 ℃;
DOI:10.1016/j.bmc.2011.02.050

Reference yield: 66.0%

: 35717-98-7
bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate

: 142631-77-4
(+)-(2R)-1-fluoro-3-(triphenylmethoxy)propan-2-ol

: 1305351-55-6
diisopropyl (R)-({[1-fluoro-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate

Guidance literature:: (+)-(2R)-1-fluoro-3-(triphenylmethoxy)propan-2-ol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at -20 ℃; for 0.5h; Inert atmosphere;

bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;
DOI:10.1016/j.bmc.2011.02.050

Reference yield:

: 129940-50-7
(S)-tritylglycidol

: 1305351-55-6
diisopropyl (R)-({[1-fluoro-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydrogenfluoride; tetra-n-butylammonium dihydrogen trifluoride / chlorobenzene / 15 h / 135 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / -20 °C / Inert atmosphere

2.2: 20 °C

With potassium hydrogenfluoride; sodium hydride; tetra-n-butylammonium dihydrogen trifluoride; In N,N-dimethyl-formamide; chlorobenzene; mineral oil;
DOI:10.1016/j.bmc.2011.02.050